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Severe Respiratory Illness Linked to Rhinovirus

Clin Infect Dis; ePub 2017 Nov 23; Prill, et al

Rhinoviruses were commonly associated with severe respiratory illness, alongside EV-D68, during a nationwide outbreak in the United States in 2014, with clinical characteristics largely similar among those with EV-D68, RV-A, RB-B, or RV-C. Respiratory specimens from pediatric and adult patients with respiratory illness were submitted to CDC during August-November 2014. Initial laboratory testing focused on identification of EV-D68, while the negative specimens were typed by molecular sequencing to identify additional enterovirus (EV) and rhinovirus (RV) types. Researchers found:

  • Among 2,629 typed specimens, 1,012 were EV-D68 and 81 (3.1%) represented other EV types; 968 were RVs (37%) covering 114 types and grouped into 3 human RV species; and 568 (22%) had no RV or EV detected.
  • EV-D68 was more frequently identified in patients presenting earlier in the study period.
  • Clinical syndromes and ICU admissions by age were largely similar among those with EV-D68 and RV species.


Prill MM, Dahl R, Midgley CM, et al. Severe respiratory illness associated with rhinovirus during the EV-D68 outbreak in the United States, August–November 2014. [Published online ahead of print November 23, 2017]. Clin Infect Dis. doi:10.1093/cid/cix1034.