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Seroreactivity to C6 Peptide in B. Miyamotoi Infections

Clin Infect Dis; ePub 2017 Nov 15; Molloy, et al

The C6 ELISA is regularly positive on convalescent phase serum samples of patients with Borrelia miyamotoi infection from the Northeastern US, a recent study found. Serum specimens from 30 patients with B. miyamotoi infection established by a polymerase chain reaction assay of a blood specimen were tested using the C6 ELISA. Researchers found:

  • 22 (91.7%) of 24 evaluable B. miyamotoi patients were C6 ELISA reactive, principally on the convalescent phase serum specimen.
  • C6 ELISA index values were often well above the positive cutoff value of 1.1, exceeding 4 in 11 of the 22 C6 ELISA reactive patients.


Molloy PJ, Weeks KE, Todd B, Wormser GP. Seroreactivity to the C6 peptide in Borrelia miyamotoi infections occurring in the Northeastern United States. [Published online ahead of print November 15, 2017]. Clin Infect Dis. doi:10.1093/cid/cix1023.