Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Next-generation sequencing can expedite surveillance/discovery of new bat coronaviruses

Key clinical point: A capture-based NGS approach using baits targeting most of the CoV species reduced sequencing costs by increasing the sensitivity of detection.

Major finding: Nine full genomes of bat CoVs were discovered, eight of which showed great genetic diversity.

Study details: RNA from previous bat surveillance samples was extracted from bat rectal swabs and analyzed using capture-based next-generation sequencing.

Disclosures: This study was supported by the Chinese government. The authors reported that they had no conflicts.


Li B et al. mSphere 2020 Jan 29;5:e00807-19.