Clinical Edge

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Next-generation sequencing can expedite surveillance/discovery of new bat coronaviruses

Key clinical point: A capture-based NGS approach using baits targeting most of the CoV species reduced sequencing costs by increasing the sensitivity of detection.

Major finding: Nine full genomes of bat CoVs were discovered, eight of which showed great genetic diversity.

Study details: RNA from previous bat surveillance samples was extracted from bat rectal swabs and analyzed using capture-based next-generation sequencing.

Disclosures: This study was supported by the Chinese government. The authors reported that they had no conflicts.

Citation:

Li B et al. mSphere 2020 Jan 29;5:e00807-19.