Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

IDSA Updates Seasonal Influenza Guidelines

Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

The Infectious Diseases Society of America (ISDA) has issued updated clinical practice guidelines on diagnosis, treatment and chemoprophylaxis with antiviral medications, and institutional outbreak management of seasonal influenza. The guidelines consider the care of children and adults, including special populations such as pregnant and postpartum women and immunocompromised patients. Among the questions addressed in the guideline recommendations:

  • Which patients should be tested for influenza?
  • Which specimens should be collected when testing for influenza?
  • What tests should be used to diagnose influenza?
  • Which patients with suspected or confirmed influenza should be treated with antivirals?
  • When should testing be done for infection with an antiviral-resistant influenza virus?
  • Who should be considered for antiviral chemoprophylaxis to prevent influenza in the absence of exposure or an institutional outbreak?
  • Which antiviral drugs should be used for preexposure chemoprophylaxis to prevent influenza?


Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza. [Published online ahead of print December 19, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy866.