The Advisory Committee on Immunization Practices (ACIP) has recommended Heplisav-B (HepB-CpG), a yeast-derived vaccine prepared with a novel adjuvant, for use in adults aged ≥18 years. The ACIP Hepatitis Vaccines Work Group conducted a systematic review of the evidence, including data from 4 randomized controlled trials assessing prevention of hepatitis B virus (HBV) infection and 6 randomized controlled trials assessing adverse events in adults. Among the findings and recommendations:
- Seroprotective antibody to hepatitis B surface antigen (anti-HBs) levels were achieved in 90.0% to 100.0% of those receiving HepB-CpG compared with 70.5% to 90.2% of subjects receiving Engerix-B.
- Heplisav-B vaccine is administered as 2 doses, 1 month apart.
- Those who should receive the vaccine include persons at risk for infection through sexual exposure, those with a history of current or recent injection drug use, and those at risk for infection by percutaneous or mucosal exposure to blood.
- Persons with hepatitis C virus (HCV) infection should also receive the vaccine, as should those with HIV, incarcerated persons, and international travelers to countries with high or intermediate levels of endemic HBV infection.
Schillie S, Harris A, Link-Gelles R, Romero J, Ward J, Nelson N. Recommendations of the Advisory Committee on Immunization Practices for use of a hepatitis B vaccine with a novel adjuvant. MMWR Morb Mortal Wkly Rep. 2018;67:455–458. doi:10.15585/mmwr.mm6715a5.
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