Patients discharged on outpatient parenteral antimicrobial therapy (OPAT) to skilled nursing facilities (SNFs) may be at higher risk for line events and more frequently lost to follow-up compared to patients discharged to home health companies (HHCs), a new study found. Researchers performed a retrospective study of 107 patients with complicated Staphylococcus aureus infections discharged on OPAT from 2 academic medical centers. Clinical characteristics, site of post-hospital care, process measure, adverse events, and clinical outcomes at 90 days were examined and comparisons made between HHCs and SNFs. Among the findings:
- 33% of patients experienced as adverse events during OPAT and 64% were readmitted at 90 days.
- At 90 days after discharge, a higher proportion of patients discharged to a SNF were lost to follow-up and had line-related adverse events.
- Patients discharged to both sites of care had similar clinical outcomes with favorable outcomes in 61% of SNF patients and 70% of HHC patients at 90 days.
- No differences in rates of relapse, readmission, or mortality were observed.
Townsend J, Keller S, Tibuakuu M, et al. Outpatient parenteral therapy for complicated Staphylococcus aureus infections: A snapshot of processes and outcomes in the real world. [Published online ahead of print October 24, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy274.
This Week's Must Reads
Must Reads in Antimicrobial-resistant infections
Antibiotic Use and Hospital Onset CDI Infection, Clin Infect Dis; ePub 2019 Mar 1; Kazakova, et al
Patient Follow-Up in OPAT & Readmissions, Clin Infect Dis; ePub 2019 Feb 27; Palms, et al
Decolonization Lowers Postdischarge Infection Risk, N Engl J Med; 2019 Feb 14; Huang, et al
Antibiotic Stewardship & Fluoroquinolone Prescribing, Clin Infect Dis; ePub 2019 Feb 13; Vaughn, et al
30-Day Readmission After S. aureus Bacteremia, Clin Infect Dis; ePub 2019 Feb 11; Inagaki, et al