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OPAT Outcomes in SNFs vs HHCs

Open Forum Infect Dis; ePub 2018 Oct 24; Townsend, et al

Patients discharged on outpatient parenteral antimicrobial therapy (OPAT) to skilled nursing facilities (SNFs) may be at higher risk for line events and more frequently lost to follow-up compared to patients discharged to home health companies (HHCs), a new study found. Researchers performed a retrospective study of 107 patients with complicated Staphylococcus aureus infections discharged on OPAT from 2 academic medical centers. Clinical characteristics, site of post-hospital care, process measure, adverse events, and clinical outcomes at 90 days were examined and comparisons made between HHCs and SNFs. Among the findings:

  • 33% of patients experienced as adverse events during OPAT and 64% were readmitted at 90 days.
  • At 90 days after discharge, a higher proportion of patients discharged to a SNF were lost to follow-up and had line-related adverse events.
  • Patients discharged to both sites of care had similar clinical outcomes with favorable outcomes in 61% of SNF patients and 70% of HHC patients at 90 days.
  • No differences in rates of relapse, readmission, or mortality were observed.


Townsend J, Keller S, Tibuakuu M, et al. Outpatient parenteral therapy for complicated Staphylococcus aureus infections: A snapshot of processes and outcomes in the real world. [Published online ahead of print October 24, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy274.