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Colistin Resistance in Patients with CRKp

Clin Infect Dis; ePub 2016 Dec 10; Rojas, et al

In patients with carbapenem-resistant Klebsiella pneumoniae (CRKp), 13% presented with colistin resistance (ColR), and mortality was increased in those with ColR isolates, a recent study found. This cohort included 246 patients with infection, or colonization with CRKp isolates tested for colistin susceptibility during the study period of December 2011 to October 2014. Researchers found:

  • 13% of patients with CRKp presented with ColR CRKp.
  • A variety of rep-PCR strain types were encountered in both the ColS and the ColR groups.
  • Carbapenem resistance was mediated primarily by blaKPC-2 (46%) and blaKPC-3 (50%).
  • ColR was associated with increased hazard for in-hospital mortality (aHR, 3.48).


Rojas LJ, Salim M, Cober E, et al. Colistin resistance in carbapenem-resistant Klebsiella pneumoniae: Laboratory detection and impact on mortality. [Published online ahead of print December 10, 2016]. Clin Infect Dis. doi:10.1093/cid/ciw805.