Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Children with resistant UTIs unexpectedly may respond to discordant antibiotics

Key clinical point: Children with third-generation cephalosporin–resistant urinary tract infections (UTIs) may improve clinically, and pyuria may resolve, during empiric treatment with an antibiotic that turns out to be discordant.

Major finding: In one multicenter study in the United States, 2% of patients had escalation of care on discordant antibiotics, and 84% had clinical improvement.

Study details: A retrospective study of 316 children with third-generation cephalosporin–resistant UTIs started on discordant antibiotic therapy.

Disclosures: The study had no external funding. The authors had no relevant financial disclosures.


Wang ME et al. Pediatrics. 2020 Jan 17. doi: 10.1542/peds.2019-1608.