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Carbapenem Resistance in Healthcare Settings

Open Forum Infect Dis; ePub 2018 Sep 21; McCann, et al

Carbapenem non-susceptible (Carb-NS) rates were significantly higher in US intensive care units (ICU) in compared to non-ICU settings, a recent study found. Researchers evaluated the rates, infection sources, and pathogen types associated with Carb-NS Gram-negative isolates in ICU and non-ICU settings in a large US hospital database. They conducted a retrospective cross-sectional analysis of carbapenem susceptibility of all non-duplicate isolates of Gram-negative pathogens collected from January 1, 2017 to December 31, 2017 at 358 US hospitals. Among the findings:

  • The Carb-NS rate for 312,075 Gram-negative isolates was 3.4% and >half were Pseudomonas.
  • The highest rates of Carb-NS were found in Acinetobacter spp. and P. aeruginosa.
  • The rate of Carb-NS was significantly higher in ICU vs non-ICU settings (5.4% vs 2.7%) and remained significant in multivariable analysis after adjusting for infection and hospital characteristics.


McCann E, Srinivasan CA, DeRyke A, et al. Carbapenem non-susceptible Gram-negative pathogens in ICU and non-ICU settings in US hospitals in 2017: A multicenter study. [Published online ahead of print September 21, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy241.