Key clinical point: Changing susceptibility profiles are driving antibiotic resistance among Streptococcus pneumoniae strains in children.
Major finding: Although minimum inhibitory concentration values decreased immediately after the introduction of 13-valent pneumococcal conjugate vaccine from 2011 to 2013, antibiotic resistance increased from 2014 to 2016.
Study details: The data come from a prospective cohort study including 1,201 isolates from 448 children aged 6-36 months during 2006-2016 in a primary care setting.
Disclosures: The study was supported in part by the National Institutes of Health and Sanofi Pasteur. Some isolates collected during the 2010-2013 time period were part of a study supported by Pfizer. The researchers had no relevant financial conflicts to disclose.
Kaur R et al. Clin Inf Dis. 2020 Feb 18. doi: 10.1093/cid/ciaa157.