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Physical Activity and Cognitive Health in HIV

J Infect Dis; ePub 2018 Aug 18; Chow, et al

Physical activity may have a greater positive impact on cognitive health in women than in men living with human immunodeficiency virus (HIV) infection, a new study found. Researchers investigated whether associations between cardiometabolic risk factors and prevalent HIV-associated cognitive impairment differ by sex. Separate logistic regression models were constructed for women and men at entry into a prospective study of older persons with HIV (PWH) to assess the association of cardiometabolic and other risk factors with cognitive impairment. They found:

  • 988 participants were included in the study (20% women).
  • Women had higher total cholesterol, hemoglobin A1c, and body mass index (BMI) compared with men and were less physically active.
  • In multivariable models, physical activity was associated with lower odds of cognitive impairment in women (OR, 0.35), but not men.


Chow FC, Makanjuola A, Wu K, et al. Physical activity is associated with lower odds of cognitive impairment in women but not men living with HIV infection. [Published online ahead of print August 18, 2018]. J Infect Dis. doi:10.1093/infdis/jiy503.

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