Bronchiolitis is not a uniform disease between respiratory syncytial virus (RSV) and rhinovirus (RV) infections, according to a recent study. A cross-sectional study of nasopharyngeal aspirates from 106 infants hospitalized with either RSV-only (n=80) or RV-only (n=26) bronchiolitis was conducted Researchers performed metabolomics analysis and 16S rRNA gene sequencing on all samples, and metagenomic sequencing on 58 or the 106 samples. They found:
- Infants with RSV-only and RV-only infections had significantly different nasopharyngeal metabolome profiles and bacterial metagenome profiles.
- RSV-only was associated with metabolites from a range of pathways and a microbiome dominated by Streptococcus pneumoniae.
- Conversely, RV-only was associated with increased essential and non-essential N-acetyl amino acids and high relative abundance of Haemophilus influenzae.
Stewart CJ, Hasegawa K, Wong MC, et al. Respiratory syncytial virus and rhinovirus bronchiolitis are associated with distinct metabolic pathways. [Published online ahead of print December 25, 2017]. J Infect Dis. doi:10.1093/infdis/jix680.
This Week's Must Reads
Antimicrobial Stewardship in the ED to Improve UTI, Open Forum Infect Dis; ePub 2018 May 2; Jorgensen, et al
Acute Respiratory Illness in Pregnant Women, J Infect Dis; ePub 2018 May 5; Hause, et al
Incidence of Syphilis in HIV-infected Persons, Clin Infect Dis; ePub 2018 Apr 24; Novak, et al
Environmental Panels to Combat MRSA and VRE, Clin Infect Dis; ePub 2018 May 2; Cassone, et al
ACIP Recommends Hepatitis B Vaccine for Adults, MMWR; 2018 Apr 20; Schillie, Harris, et al
Must Reads in Pediatrics
Antibiotic Selection Pressure & Macrolide Resistance, Clin Infect Dis; ePub 2018 Apr 20; Keenan, et al
Antibiotic Administration for CAP & Length of Stay, J Pediatr Infect Dis; ePub 2018 Feb 8; Christensen, et al
Understanding C. difficile Patterns in Children, Clin Infect Dis; ePub 2018 Jan 23; Kociolek, et al
PIDS/IDSA Criteria Validation in Children with CAP, Clin Infect Dis; ePub 2018 Jan 13; Florin, et al
Rotavirus Vaccine & Risk of Seizures in Children, J Infect Dis; ePub 2018 Jan 9; Pringle, et al