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Influenza Vaccine Effectiveness & Early Exposures

J Infect Dis; ePub 2018 Jan 18; Flannery, et al

There is an association between reduced vaccine effectiveness (VE) against influenza A(H1N1)pdm09-related illness during 2015-2016 in the US and early exposure to specific influenza A(H1N1) viruses, a new study suggests. Researchers estimated the effectiveness of influenza vaccine against polymerase chain reaction-confirmed influenza A(H1N1)pdm09-associated medically attended illness from the 2010-2011 season through the 2015-2016 season, according to a patient birth cohort. They found:

  • 2,115 A(H1N1)pdm09 virus-positive and 14,696 influenza virus-negative patients aged ≥6 months were included in the analysis.
  • VE was 61% against A(H1N1)pdm09-associated illness during the 2010-2011 through 2013-2014 seasons vs 47% during 2015-2016.
  • During 2015-2016, A(H1N1)pdm09-specific VE was 22% among adults born during 1958-1979 vs 61% for all other birth cohorts combined.


Flannery B, Smith C, Garten RJ, et al. Influence of birth cohort on effectiveness of 2015-2016 influenza vaccine against medically attended illness due to 2009 pandemic influenza A(H1N1) virus in the United States. [Published online ahead of print January 18, 2018]. J Infect Dis. doi:10.1093/infdis/jix634.

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