Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Efficacy of Oseltamivir in Children Evaluated

Clin Infect Dis; ePub 2017 Nov 23; Malosh, et al

Treatment with oseltamivir significantly reduced the duration of illness in those with influenza and lowered the risk of developing otitis media, a recent study found. The systematic review and meta-analysis identified randomized clinical trials (RCTs) of oseltamivir therapy in children. 5 trials were identified and included 2,561 patients in the intent to treat (ITT) and 1,598 patients in the intent to treat infected (ITTI) population. Researchers found:

  • Overall, oseltamivir treatment significantly reduced the duration of illness in the ITTI population (restricted mean survival time [RMST] difference ‒17.6 hours).
  • In trials enrolling patients without asthma, the difference was larger (‒29.9 hours).
  • Risk of otitis media was 34% lower in the ITTI population.
  • The only adverse event with a significantly higher risk in the treatment group was vomiting.

Citation:

Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS. Efficacy and safety of oseltamivir in children: Systematic review and individual patient data meta-analysis of randomized controlled trials. [Published online ahead of print November 23, 2017]. Clin Infect Dis. doi:10.1093/cid/cix1040.

This Week's Must Reads

Statin Use & Increased Influenza Risk, Clin Infect Dis; ePub 2018 Feb 9; Izurieta, et al

Socioeconomic Status & Risk of Infection & Sepsis, Clin Infect Dis; ePub 2018 Feb 12; Donnelly, et al

Antibiotic Administration for CAP & Length of Stay, J Pediatr Infect Dis; ePub 2018 Feb 8; Christensen, et al

Prophylactic Antimicrobial Therapy for AAP, Clin Infect Dis; ePub 2018 Feb 9; Dragan, et al

CDC Metric for Measuring & Comparing Antibiotic Use, Clin Infect Dis; ePub 2018 Feb 2; van Santen, et al

Must Reads in Influenza

Statin Use & Increased Influenza Risk, Clin Infect Dis; ePub 2018 Feb 9; Izurieta, et al

Acute Myocardial Infarction After Influenza , N Engl J Med; 2018 Jan 25; Kwong, Schwartz, et al

Influenza Vaccine Effectiveness & Early Exposures , J Infect Dis; ePub 2018 Jan 18; Flannery, et al

FDA Expands Indication for Influenza Vaccine, GSK news release; 2018 Jan 11

Seasonal Influenza A & Antiviral Tx for Patients, CDC Health Advisory; 2017 Dec 27; CDC