Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Penicillin Allergy and MSSA Bacteremia
Open Forum Infect Dis; ePub 2018 Feb 19; Turner, et al
Reported penicillin allergy had no significant effect on 30- or 90-day mortality in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, a recent study found. The retrospective cohort study of adults with MSSA bacteremia from 2010-2015 included 318 patients with MSSA bacteremia. Outcomes were examined according to reported penicillin allergy. Researchers found:
- Reported penicillin allergy had no significant effect on adjusted 30-day mortality (OR, 0.73).
- Patients with reported penicillin allergy were more likely to receive vancomycin, but a large number received cefazolin regardless of reported allergy.
- Non-penicillin allergic patients receiving vancomycin for treatment of MSSA bacteremia had the highest mortality rates overall.
- Receipt of a beta-lactam was the strongest predictor of survival.
Turner NA, Moehring R, Sarubbi C, et al. Influence of reported penicillin allergy on mortality in MSSA bacteremia. Open Forum Infect Dis. [Published online ahead of print February 19, 2018]. doi:10.1093/ofid/ofy042.
This Week's Must Reads
Antibiotic Stewardship Programs in Acute Care, Clin Infect Dis; ePub 2018 Mar 26; Doernberg, et al
Increases in HPV Vaccination in Males in the United States, J Infect Dis; ePub 2018 Mar 23; Patel, et al
Prevalence of Trichomonas vaginalis Infection in US, Clin Infect Dis; ePub 2018 Mar 15; Patel, et al
Challenges in Patients with HIV/TB Coinfection, Open Forum Infect Dis; ePub 2018 Mar 21; Schechter, et al
Female HIV-1 Risk in Pregnancy and Postpartum, J Infect Dis; ePub 2018 Mar 5; Thomson, et al
Must Reads in Hospital-acquired Infections
Colonization as a Risk Factor for S. aureus, BMC Infect Dis; ePub 2018 Feb 21; Kim, et al
Penicillin Allergy and MSSA Bacteremia , Open Forum Infect Dis; ePub 2018 Feb 19; Turner, et al
SSI Incidence After Gastrointestinal Surgery , Lancet Infect Dis; ePub 2018 Feb 13; Bhangu, et al
Socioeconomic Status & Risk of Infection & Sepsis, Clin Infect Dis; ePub 2018 Feb 12; Donnelly, et al
Regional Spread of CRE Among Healthcare Facilities, Clin Infect Dis; ePub 2018 Feb 3; Ray, et al