Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Penicillin Allergy and MSSA Bacteremia

Open Forum Infect Dis; ePub 2018 Feb 19; Turner, et al

Reported penicillin allergy had no significant effect on 30- or 90-day mortality in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, a recent study found. The retrospective cohort study of adults with MSSA bacteremia from 2010-2015 included 318 patients with MSSA bacteremia. Outcomes were examined according to reported penicillin allergy. Researchers found:

  • Reported penicillin allergy had no significant effect on adjusted 30-day mortality (OR, 0.73).
  • Patients with reported penicillin allergy were more likely to receive vancomycin, but a large number received cefazolin regardless of reported allergy.
  • Non-penicillin allergic patients receiving vancomycin for treatment of MSSA bacteremia had the highest mortality rates overall.
  • Receipt of a beta-lactam was the strongest predictor of survival.

Citation:

Turner NA, Moehring R, Sarubbi C, et al. Influence of reported penicillin allergy on mortality in MSSA bacteremia. Open Forum Infect Dis. [Published online ahead of print February 19, 2018]. doi:10.1093/ofid/ofy042.

This Week's Must Reads

ED Visits for ADEs From Antibiotics in Children, J Pediatric Infect Dis Soc; ePub 2018 Aug 23; Lovegrove, et al

Food Insecurity & Inflammation in Women Living with HIV, J Infect Dis; ePub 2018 Aug 27; Leddy, et al

Racial and Ethnic Disparities in HIV Care, Clin Infect Dis; ePub 2018 Aug 31; Desir, et al

Outcomes of Community & Hospital-Onset CDI, Clin Infect Dis; ePub 2018 Aug 23; Pinzon, et al

MRSA Infections After Hospital Discharge, Clin Infect Dis; ePub 2018 Aug 11; Nelson, et al

Must Reads in Healthcare-acquired Infections

Outcomes of Community & Hospital-Onset CDI, Clin Infect Dis; ePub 2018 Aug 23; Pinzon, et al

MRSA Infections After Hospital Discharge, Clin Infect Dis; ePub 2018 Aug 11; Nelson, et al

Sepsis and Risk of Cancer in Elderly Adults, Clin Infect Dis; ePub 2018 Jul 4; Liu, et al

Decreasing Incidence of SSTIs at US EDs, Clin Infect Dis; ePub 2018 Jun 15; Morgan, et al

ID Consultation & Clinical Outcomes in SAB, Open Forum Infect Dis; ePub 2018 Jun 14; Yousaf, et al