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Symptom-Based Scores for Acute HIV Diagnosis

Clin Infect Dis; ePub 2017 Dec 25; Lin, et al

A 3-symptom score accurately predicted acute HIV infection in a community-based screening program, a recent study found. Adults who tested either positive for AHI or HIV nucleic acid test or HIV NAT-negative with the community-based Early Test HIV screening program in San Diego were retrospectively randomized 2:1 into a derivation and validation set. In the former, symptoms significant for AHI were assigned a score value. The score was assessed in the validation set using receiver operating characteristics and areas under the curve (AUC). Researchers found:

  • Among 998 participants, 113 had AHI.
  • Compared to HIV-negative cases, AHI cases reported more symptoms.
  • Fever, myalgia, and weight loss were significantly associated with AHI in the multivariate model and corresponded to 11, 8, and 4 score points, respectively.
  • The summed scored yielded AUC of 0.85.

Citation:

Lin TC, Gianella S, Tenenbaum T, Little SJ, Hoenigl M. A simple symptom score for acute HIV infection in a San Diego community based screening program. [Published online ahead of print December 25, 2017]. Clin Infect Dis. doi:10.1093/cid/cix1130.

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