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Predictors of Longitudinal PrEP Adherence Among MSM

J Infect Dis; ePub 2018 Jun 22; Pasipanodya, et al

The use of text-reported pre-exposure prophylaxis (PrEP) adherence was favorable among men who have sex with men (MSM), a recent study found. The randomized controlled trial of text-messaging vs standard of care for PrEP adherence included 181 MSM who received once-daily tenofovir disoproxil fumarate/emtricitabine and daily adherence texts for 48 weeks. Growth Mixture Modeling (GMM) was used to identify subgroups of individuals with similar trajectories of text-reported adherence. Between-groups differences in pharmacologic measures of adherence as well as predictors and study-end attitudes associated with group membership, were examined. Researchers found:

  • 4 trajectories of text-reported adherence were identified.
  • Classes with higher text-reported adherence had higher drug concentrations.
  • Younger age and minority race were associated with lower adherence.
  • Individuals in classes with lower adherence had greater baseline levels of depression, substance abuse concerns, and sexual risk.
  • Differences in study satisfaction were also associated with adherence.

Citation:

Pasipanodya EC, Jain S, Sun X, et al. Trajectories and predictors of longitudinal PrEP adherence among men who have sex with men. [Published online ahead of print June 22, 2018]. J Infect Dis. doi:10.1093/infdis/jiy368.

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