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Incidence of Syphilis in HIV-infected Persons

Clin Infect Dis; ePub 2018 Apr 24; Novak, et al

There has been an increase in the incidence of syphilis in HIV-infected persons in the US through 2015, especially among gay, bisexual, and other men who have sex with men (MSM), a recent study found. Researchers analyzed data from the HIV Outpatient Study (HOPS) cohort participants seen at 10 US HIV clinics during 1999-2015. They found:

  • 6,888 HIV-infected persons were included (78% male, aged 31-50 years; 56% were MSM); 641 had ≥1 new syphilis diagnoses during a median follow-up of 5.2 years.
  • There were 799 syphilis diagnoses for an overall incidence of 1.8 per 100 person-years.
  • Incidence rate increase from 0.4 to 2.2 per 100 person-years during the study period.
  • Risk factors identified for syphilis included being aged 18-30 years vs 31-40 years, being MSM vs heterosexual male, and being non-Hispanic black vs non-Hispanic white.

Citation:

Novak RM, Ghanem A, Hart R, Ward D, Armon C, Buchacz K, HIV Outpatient Study Investigators. Risk factors and incidence of syphilis in HIV-infected persons, the HIV Outpatient Study, 1999-2015. [Published online ahead of print April 24, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy348.

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