Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Frailty & Neurocognitive Impairment in PLWH

Clin Infect Dis; ePub 2018 May 18; Erlandson, et al

In people living with HIV (PLWH), the presence of frailty with neurocognitive impairment (NCI) was associated with a greater risk of falls, disability or death than NCI alone, a recent study found. Participants in the longitudinal, observational study of aging completed entry evaluations for frailty and NCI. Outcomes were falls (recurrent), increased limitations in independent activities of daily living, or mortality and were combined. Among the study details:

  • Among 987 participants (median age at entry 51 years, 19% female) median CD4 count was 616 cells/µL, and HIV-RNA was <200 copies/mL in 94%.
  • 79% of participants had neither frailty nor NCI, 2% had both, 4% had frailty only, and 15% had NCI only.
  • Over 2 years of observation, 100 (10%) participants experienced recurrent falls, 175 (18%) worsening IADL limitation, 17 (2%) died, and 254 (26%) had at least 1 of these poor health outcomes.
  • In adjusted models, frailty with NCI was associated with more than double the risk of poor health outcome.

Citation:

Erlandson KM, Perez J, Abdo M, et al. Frailty, neurocognitive impairment, or both in predicting poor health outcomes among adults living with HIV. [Published online ahead of print May 18, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy430.

This Week's Must Reads

New IDSA Guideline for Management of OPAT, Clin Infect Dis; ePub 2018 Nov 13; Norris, et al

Immunocompromised Children with Influenza, J Pediatric Infect Dis Soc; ePub 2018 Oct 25; Collins, et al

OPAT Outcomes in SNFs vs HHCs, Open Forum Infect Dis; ePub 2018 Oct 24; Townsend, et al

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Mycoplasma Genitalium Infections & STIs, Clin Infect Dis; ePub 2018 Oct 23; Lillis, et al

Must Reads in HIV

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Sex Differences in HIV-associated Cognitive Impairment, AIDS; ePub 2018 Oct 4; Sundermann, et al

Parenting Desires in Men & Women Living with HIV, Open Forum Infect Dis; ePub 2018 Sep 15; Cohn, et al

Mobile Health Intervention for PrEP in Young MSM, Clin Infect Dis; ePub 2018 Sep 15; Liu, et al

Food Insecurity & Inflammation in Women Living with HIV, J Infect Dis; ePub 2018 Aug 27; Leddy, et al