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Opioid Substitution Therapy in HCV Patients

J Infect Dis; ePub 2017 Dec 26; Stepanova, et al

Receiving interferon-free regimens led to patient-reported outcome (PRO) improvement during treatment for hepatitis C virus (HCV) and after SVR regardless of opioid substitution therapy (OST) status, a recent study found. Patients were enrolled in phase 3 clinical trials of sofosbuvir and completed 4 PRO instruments: SF-36V2, FACIT-F, CLDQ-HCV, and WPAI-HCV before, during, and post-treatment. 8,450 HCV individuals were included; 407 (4.8%) were on OST. Researchers found:

  • At baseline, OST participants had significantly lower PRO scores.
  • By treatment completion, those receiving IFN+RBV+SOF experienced significant decreases in PROs regardless of OST use.
  • Those receiving IFN-free RBV+ regimens had significant but smaller PRO decreases; similar in OST and non-OST.
  • Those treated with IFN/RBV-free regimens showed improvement in nearly all PROs during treatment which was more pronounced in OST individuals.


Stepanova M, Thompson A, Doyle J, Younossi I, de Avila L, Younossi ZM. Hepatitis C patients receiving opioid substitution therapy experience improvement in patient-reported outcomes following treatment with interferon-free regimens. [Published online ahead of print December 26, 2017]. J Infect Dis. doi:10.1093/infdis/jix681.

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