Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Opioid Substitution Therapy in HCV Patients

J Infect Dis; ePub 2017 Dec 26; Stepanova, et al

Receiving interferon-free regimens led to patient-reported outcome (PRO) improvement during treatment for hepatitis C virus (HCV) and after SVR regardless of opioid substitution therapy (OST) status, a recent study found. Patients were enrolled in phase 3 clinical trials of sofosbuvir and completed 4 PRO instruments: SF-36V2, FACIT-F, CLDQ-HCV, and WPAI-HCV before, during, and post-treatment. 8,450 HCV individuals were included; 407 (4.8%) were on OST. Researchers found:

  • At baseline, OST participants had significantly lower PRO scores.
  • By treatment completion, those receiving IFN+RBV+SOF experienced significant decreases in PROs regardless of OST use.
  • Those receiving IFN-free RBV+ regimens had significant but smaller PRO decreases; similar in OST and non-OST.
  • Those treated with IFN/RBV-free regimens showed improvement in nearly all PROs during treatment which was more pronounced in OST individuals.

Citation:

Stepanova M, Thompson A, Doyle J, Younossi I, de Avila L, Younossi ZM. Hepatitis C patients receiving opioid substitution therapy experience improvement in patient-reported outcomes following treatment with interferon-free regimens. [Published online ahead of print December 26, 2017]. J Infect Dis. doi:10.1093/infdis/jix681.

This Week's Must Reads

New IDSA Guideline for Management of OPAT, Clin Infect Dis; ePub 2018 Nov 13; Norris, et al

Immunocompromised Children with Influenza, J Pediatric Infect Dis Soc; ePub 2018 Oct 25; Collins, et al

OPAT Outcomes in SNFs vs HHCs, Open Forum Infect Dis; ePub 2018 Oct 24; Townsend, et al

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Mycoplasma Genitalium Infections & STIs, Clin Infect Dis; ePub 2018 Oct 23; Lillis, et al

Must Reads in Hepatitis

Mortality in US Patients with Chronic HBV, Clin Infect Dis; ePub 2018 Jul 28; Bixler, et al

Pregnancy Outcomes in Women with HBV , Open Forum Infect Dis; ePub 2018 Jun 9; Bajema, et al

HBV Prevention in Foreign-Born Women, Clin Infect Dis; ePub 2018 Jun 1; Kilmer, et al

ACIP Recommends Hepatitis B Vaccine for Adults, MMWR; 2018 Apr 20; Schillie, Harris, et al

HCV Treatment as Prevention in PWIDs, Lancet; 2018 Feb; Zelenev, Li, et al