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Opioid Substitution Therapy in HCV Patients

J Infect Dis; ePub 2017 Dec 26; Stepanova, et al

Receiving interferon-free regimens led to patient-reported outcome (PRO) improvement during treatment for hepatitis C virus (HCV) and after SVR regardless of opioid substitution therapy (OST) status, a recent study found. Patients were enrolled in phase 3 clinical trials of sofosbuvir and completed 4 PRO instruments: SF-36V2, FACIT-F, CLDQ-HCV, and WPAI-HCV before, during, and post-treatment. 8,450 HCV individuals were included; 407 (4.8%) were on OST. Researchers found:

  • At baseline, OST participants had significantly lower PRO scores.
  • By treatment completion, those receiving IFN+RBV+SOF experienced significant decreases in PROs regardless of OST use.
  • Those receiving IFN-free RBV+ regimens had significant but smaller PRO decreases; similar in OST and non-OST.
  • Those treated with IFN/RBV-free regimens showed improvement in nearly all PROs during treatment which was more pronounced in OST individuals.

Citation:

Stepanova M, Thompson A, Doyle J, Younossi I, de Avila L, Younossi ZM. Hepatitis C patients receiving opioid substitution therapy experience improvement in patient-reported outcomes following treatment with interferon-free regimens. [Published online ahead of print December 26, 2017]. J Infect Dis. doi:10.1093/infdis/jix681.

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