Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Low Plasma 25(OH)D and Risk of Sepsis

Open Forum Infect Dis; ePub 2018 Sep 18; Kempker, et al

Low plasma 25-hydroxyvitamin D 25(OH)D measured at the time of relative health was independently associated with increased risk of sepsis in a cohort of community-dwelling US adults. Participants were selected from the Reasons for Geographic and Racial Differences in Stroke study (REGARDS), a US cohort of 30,239 adults aged ≥45 years. Researchers measured baseline plasma 25(OH)D in 711 sepsis cases and in 992 participants randomly selected from the cohort. They found:

  • Median age of participants in the study sample was 65 years (41% black, 45% male).
  • Mean plasma 25-hydroxyvitamin D concentrations was 25.8 ng/ml with 31% of individuals <20 ng/ml.
  • The adjusted risk of community-acquired sepsis was higher for each lower category of baseline 25(OH)D.
  • Results did not differ in analyses stratified by race or age.

Citation:

Kempker JA, Panwar B, Judd SE, Jenny NS, Wang HE, Gutiérrez OM. Plasma 25-hydroxyvitamin D and the longitudinal risk of sepsis in the REGARDS cohort. [Published online ahead of print September 18, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy794.

This Week's Must Reads

New IDSA Guideline for Management of OPAT, Clin Infect Dis; ePub 2018 Nov 13; Norris, et al

Immunocompromised Children with Influenza, J Pediatric Infect Dis Soc; ePub 2018 Oct 25; Collins, et al

OPAT Outcomes in SNFs vs HHCs, Open Forum Infect Dis; ePub 2018 Oct 24; Townsend, et al

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Mycoplasma Genitalium Infections & STIs, Clin Infect Dis; ePub 2018 Oct 23; Lillis, et al

Must Reads in Healthcare-acquired Infections

Better Management of OPAT Can Reduce Readmissions, Clin Infect Dis; ePub 2018 Sep 21; Shah, et al

Low Plasma 25(OH)D and Risk of Sepsis, Open Forum Infect Dis; ePub 2018 Sep 18; Kempker, et al

Long-Acting Opioid Use & Risk of Infections, Clin Infect Dis; ePub 2018 Sep 15; Wiese, et al

Outcomes of Community & Hospital-Onset CDI, Clin Infect Dis; ePub 2018 Aug 23; Pinzon, et al

MRSA Infections After Hospital Discharge, Clin Infect Dis; ePub 2018 Aug 11; Nelson, et al