Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Long-Acting Opioid Use & Risk of Infections

Clin Infect Dis; ePub 2018 Sep 15; Wiese, et al

Among long-acting adult opioid users, the risk of serious infections varies by opioid type, a recent study found. The retrospective cohort study included Tennessee Medicaid enrollees aged ≥18 years initiating long-acting opioids from 1995-2015. Hospitalizations for serious infection were identified using validated coding algorithms. Researchers compared the risk of infection among patients using long-acting opioids with known immunosuppressive properties (morphine, fentanyl, methadone) to patients using long-acting opioids without immunosuppressive properties (oxycodone, oxymorphone, tramadol). Users of individual long-acting opioids were also compared to long-acting morphine users. Among the findings:

  • 1,906 serious infections were identified among the 61,240 patients initiating opioids with immunosuppressive properties and 22,811 patients initiating opioids without immunosuppressive properties.
  • Non-immunosuppressive opioid users had a lower rate of infection vs immunosuppressive opioid users.
  • Oxycodone users had a lower rate of infection vs morphine users.

Citation:

Wiese AD, Griffin MR, Schaffner W, et al. Long-acting opioid use and the risk of serious infections: A retrospective cohort study. [Published online ahead of print September 15, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy809.

This Week's Must Reads

Carbapenem Resistance in Healthcare Settings, Open Forum Infect Dis; ePub 2018 Sep 21; McCann, et al

UATs for SP and LP in Community-acquired Pneumonia, Clin Infect Dis; ePub 2018 Sep 28; Bellew, et al

Better Management of OPAT Can Reduce Readmissions, Clin Infect Dis; ePub 2018 Sep 21; Shah, et al

Low Plasma 25(OH)D and Risk of Sepsis, Open Forum Infect Dis; ePub 2018 Sep 18; Kempker, et al

Long-Acting Opioid Use & Risk of Infections, Clin Infect Dis; ePub 2018 Sep 15; Wiese, et al

Must Reads in Healthcare-acquired Infections

Better Management of OPAT Can Reduce Readmissions, Clin Infect Dis; ePub 2018 Sep 21; Shah, et al

Low Plasma 25(OH)D and Risk of Sepsis, Open Forum Infect Dis; ePub 2018 Sep 18; Kempker, et al

Long-Acting Opioid Use & Risk of Infections, Clin Infect Dis; ePub 2018 Sep 15; Wiese, et al

Outcomes of Community & Hospital-Onset CDI, Clin Infect Dis; ePub 2018 Aug 23; Pinzon, et al

MRSA Infections After Hospital Discharge, Clin Infect Dis; ePub 2018 Aug 11; Nelson, et al