Metformin use during treatment for tuberculosis (TB) was associated with decreased mortality, suggesting its potential use as adjunctive, host-directed therapy, a recent study found. The retrospective cohort study included 2,416 patients aged ≥13 years undergoing treatment for culture-confirmed, drug-susceptible pulmonary TB. The effect of diabetes mellitus (DM) on mortality during TB treatment was assessed as well as 2-month sputum culture conversion. The effect of metformin use on survival during TB treatment was also evaluated. Researchers found:
- After adjustments, patients with DM had 1.91 times higher odds of death during TB treatment than patients without DM, and 1.72 times higher odds of remaining culture-positive at 2 months.
- Metformin use in patients with DM was significantly associated with decreased mortality during TB treatment (HR, 0.56).
- Metformin users had similar mortality as patients without DM.
Degner NR, Wang J-Y, Golub JE, Karakousis PC. Metformin use reverses the increased mortality associated with diabetes mellitus during tuberculosis treatment. [Published online ahead of print September 19, 2017]. Clin Infect Dis. doi:10.1093/cid/cix819.
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