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Immunity Duration After Poliovirus Booster

J Infect Dis; ePub 2016 Dec 21; John, et al

Protection against poliovirus in children remained elevated 6 and 11 months after an inactivated poliovirus vaccine (IPV) boost, a recent study found, although at a lower level than reported at 1 month. This open-label, randomized controlled trial was conducted to assess the duration of the boost in intestinal immunity following a dose of IPV given to oral vaccine (OPV)-immunized children. 900 healthy children aged 1 to 4 years were randomized 1:1:1 to receive IPV at 5 months (arm A), at enrollment (arm B), or no vaccine (arm C). Primary outcome was poliovirus shedding in stool 7 days after bivalent OPV challenge at 11 months. Researchers found:

  • 284 (94.7%), 297 (99.0%), and 296 (98.7%) children in arms A, B and C, respectively, were eligible for primary per-protocol analysis.
  • Poliovirus shedding 7 days after challenge was less prevalent in arms A and B compared with arm C.

Citation:

John J, Giri S, Karthikeyan AS, et al. The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomized controlled trial. [Published online ahead of print December 21, 2016]. J Infect Dis. doi:10.1093/infdis/jiw595.

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