Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antimicrobial Therapy for Enterococcus faecalis

Clin Infect Dis; ePub 2018 Jan 30; Beganovic, et al

Combination antimicrobial therapy may be the best cure for Enterococcus faecalis bloodstream infections and infective endocarditis, according to a recent review, which highlights treatment options, their limitations, and provides direction for future investigative efforts to aid in the treatment of these severe infections. The review notes:

  • While ampicillin plus ceftriaxone had emerged as a preferred option, mortality rates continue to be high with ceftriaxone promoting colonization with vancomycin resistant-enterococci due to high biliary concentrations.
  • The review also stresses that more research is needed to improve patient outcomes.

Citation:

Beganovic M, Luther MK, Ric LB, Arias CA, Rybak MJ, LaPlante KL. A review of combination antimicrobial therapy for Enterococcus faecalis bloodstream infections and infective endocarditis. [Published online ahead of print January 30, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy064.

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