Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antimicrobial Therapy for Enterococcus faecalis

Clin Infect Dis; ePub 2018 Jan 30; Beganovic, et al

Combination antimicrobial therapy may be the best cure for Enterococcus faecalis bloodstream infections and infective endocarditis, according to a recent review, which highlights treatment options, their limitations, and provides direction for future investigative efforts to aid in the treatment of these severe infections. The review notes:

  • While ampicillin plus ceftriaxone had emerged as a preferred option, mortality rates continue to be high with ceftriaxone promoting colonization with vancomycin resistant-enterococci due to high biliary concentrations.
  • The review also stresses that more research is needed to improve patient outcomes.

Citation:

Beganovic M, Luther MK, Ric LB, Arias CA, Rybak MJ, LaPlante KL. A review of combination antimicrobial therapy for Enterococcus faecalis bloodstream infections and infective endocarditis. [Published online ahead of print January 30, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy064.

This Week's Must Reads

Antimicrobial Stewardship in the ED to Improve UTI, Open Forum Infect Dis; ePub 2018 May 2; Jorgensen, et al

Acute Respiratory Illness in Pregnant Women, J Infect Dis; ePub 2018 May 5; Hause, et al

Incidence of Syphilis in HIV-infected Persons, Clin Infect Dis; ePub 2018 Apr 24; Novak, et al

Environmental Panels to Combat MRSA and VRE, Clin Infect Dis; ePub 2018 May 2; Cassone, et al

ACIP Recommends Hepatitis B Vaccine for Adults, MMWR; 2018 Apr 20; Schillie, Harris, et al

Must Reads in Antimicrobial Resistance

Antimicrobial Stewardship in the ED to Improve UTI, Open Forum Infect Dis; ePub 2018 May 2; Jorgensen, et al

Environmental Panels to Combat MRSA and VRE, Clin Infect Dis; ePub 2018 May 2; Cassone, et al

Antibiotic Selection Pressure & Macrolide Resistance, Clin Infect Dis; ePub 2018 Apr 20; Keenan, et al

Racial Disparities in Invasive MRSA Infections, Clin Infect Dis; ePub 2018 Apr 5; Gualandi, et al

Antibiotic Stewardship to Improve Treatment of URI and SSTI, Clin Infect Dis; ePub 2018 Mar 30; Jenkins, et al