Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antibiotic Stewardship Programs in Acute Care

Clin Infect Dis; ePub 2018 Mar 26; Doernberg, et al

In an acute care setting, prospective audit and feedback should be the cornerstone of antibiotic stewardship programs, and both physician leadership and pharmacists with expertise in stewardship are crucial for success. This according to a recent cross-sectional survey of members of 3 infectious diseases subspecialty societies actively involved in antibiotic stewardship. Among the survey details:

  • 244 respondents from a variety of acute care settings were included.
  • Prior authorization for select antibiotics, antibiotic reviews with prospective audit and feedback, and guideline development were common strategies.
  • 85% of surveyed programs demonstrated effectiveness in at least 1 outcome in the prior 2 years.
  • Each 0.50 increase in physician and pharmacist full-time equivalent support predicted a 1.48-fold increase in the odds of demonstrating effectiveness.
  • Most programs noted significant barriers to success.


Doernberg SB, Abbo LM, Burdette SD, et al. Essential resources and strategies for antibiotic stewardship programs in the acute care setting. [Published online ahead of print March 26, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy255.

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