Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Corticosteroid use poses risk of febrile neutropenia
Chao CR et al. J Natl Compr Canc Netw. 2018;16(10):1201-8
Key clinical point: Risk factors for chemotherapy-induced febrile neutropenia include corticosteroid use and intravenous antibiotics.
Major finding: Corticosteroid use was associated with an increased risk of febrile neutropenia, compared with no corticosteroid use (hazard ratio, 1.53; P less than .01).
Study details: This retrospective study included 15,971 patients with non-Hodgkin lymphoma or five solid tumors.
Disclosures: The study was funded by Amgen. Three of the authors reported being employers and stockholders of Amgen.
Chao CR et al. J Natl Compr Canc Netw. 2018;16(10):1201-8
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'New standard of care’ for CLL in younger patients, Shanafelt TD et al. ASH 2018, Abstract LBA-4
Mutation pegged as CLL resistance mechanism to venetoclax, Blombery P et al. ASH 2018, Abstract LBA-7
Guidelines for primary central nervous system lymphoma, Fox et al. Br J Haematol. 2018 Nov 23 doi: 10.1111/bjh.15661
FLYER evaluates number of R-CHOP cycles in DLBCL, Poeschel V et al. ASH 2018, Abstract 781
Ibrutinib-based therapy improves survival in CLL, Woyach JA et al. ASH 2018, Abstract 6