Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Blacks Fare Better After This Type of Transplant

Biol Blood Marrow Transplant.; ePub 2018 Jan 25; Solomon, et al

Black patients appear to experience less disease relapse than whites following post-transplant cyclophosphamide-based haploidentical donor transplantation (PTCy-HIDT), according to an analysis involving 203 individuals. Participants were a median age of 53 years and comprised blacks (n=80) and whites (n=123) who underwent first PTCy-HIDT for hematologic malignancies at a single center. Peripheral blood stem cell was used in two-thirds of patients, and 4 in every 10 received myeloablative conditioning. Among the results:

  • 3-year overall survival, disease-free survival, and relapse rates in blacks were 72%, 65%, and 25%, respectively.
  • These rates in whites were 50%, 45%, and 39%, respectively.
  • Non-relapse mortality, acute graft-versus-host disease (GVHD), and moderate-to-severe chronic GVHD rates were similar in both groups.
  • Improved survival was seen in all black patient subgroups.
  • Blacks were 53% more likely than whites to experience better overall survival.
  • They were 51% more likely to experience better disease-free survival.


Solomon S, Zhang X, Holland H, Morris L, Solh M, Bashey A. Superior survival of black versus white patients following post-transplant cyclophosphamide-based haploidentical transplantation for adults with hematologic malignancy. [Published online ahead of print January 25, 2018]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2018.01.024.

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