Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

RELEVANCE data sheds light on follicular lymphoma treatment

Morschhauser F et al. N Engl J Med. 2018;379:934-47.

Key clinical point: Rituximab plus lenalidomide was as effective as rituximab with chemotherapy but with a different safety profile.

Major finding: Complete responses were seen in 48% of rituximab/lenalidomide patients versus 53% in the rituximab/chemotherapy patients (P = .13).

Study details: A phase 3 superiority trial of 1,030 patients with previously untreated follicular lymphoma.

Disclosures: Celgene and the Lymphoma Academic Research Organization funded the study. The authors reported various disclosures, including financial ties to Celgene.

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Morschhauser F et al. N Engl J Med. 2018;379:934-47.

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