Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Updated CLL guidelines

Hallek M et al. Blood

Major changes or additions to new guidelines for chronic lymphocytic leukemia include the following:

Molecular genetics: Recognition of the clinical importance of specific genomic alterations/mutations 17p deletion and mutations in TP53 on therapeutic response.

IGHV mutational status: Immunoglobulin variable heavy chain (IGHV) genes offer important prognostic information.

Biomarkers: Soluble CD23, thymidine kinase, and beta-2-microglobulin need to be standardized and used in prospective clinical trials.

MRD: Minimal residual disease should be assessed in clinical trials aimed at maximizing remission depth.

Antiviral prophylaxis: Patients should be tested for HBV serological status before starting on an anti-CD20 agent.

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Hallek M et al. Blood

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Must Reads in CLL

Updated CLL guidelines, Hallek M et al. Blood

Prognostic Testing Patterns, CLL Outcomes Assessed, Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 5; Mato, et al

Liver Dysfunction in Chronic Lymphocytic Leukemia, Am J Hematol; ePub 2017 Oct 19; Hampel, et al

Agent Orange’s Impact on CLL in Vietnam Veterans, Leuk Lymphoma; ePub 2017 Sep 14; Mescher, et al

Survival in Older Patients with CLL/SLL Evaluated, Clin Lymphoma Myeloma Leuk; ePub 2017 Jul 18; Ammann, et al