Key clinical point: CLL relapsed after therapy with a B-cell receptor signaling inhibitor has a rapidly progressive course, requiring quick ramp up of venetoclax.
Major finding: All patients reached the target dose of venetoclax, with only two cases of manageable clinical tumor lysis syndrome.
Study details: Retrospective analysis of outcomes for 15 patients with chronic lymphocytic leukemia relapsed after treatment with a B-cell receptor signaling inhibitor.
Disclosures: The study was internally funded. Dr. Awan receives research funding from Gilead, Pharmacyclics. AbbVie and Janssen.
Source: Awan F et al. European Hematology Association 2018 Annual Congress. Abstract PF357
Awan F et al. European Hematology Association 2018 Annual Congress. Abstract PF357
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Escalating venetoclax dose was safe in relapsed CLL, Koenig K et al. EHA Congress (annual meeting of the European Hematology Association), Abstract PF357.