Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New guidelines from the UK on chronic lymphocytic leukemia

Schuh AH et al. Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460

Key clinical point: Fludarabine, cyclophosphamide, and rituximab should be first-line therapy for patients with chronic lymphocytic leukemia (CLL) without TP53 disruption.

Major finding: All patients diagnosed with CLL should be tested for TP53 disruption.

Study details: A guideline developed by the British Society for Haematology offering recommendations for CLL treatment outside clinical trials.

Disclosures: The guideline development was supported by the British Society for Haematology. The UK CLL Forum is a registered charity that receives funding from a number of pharmaceutical companies.

Read the article.


Schuh AH et al. Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460.

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