Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

What to Know About a Second-Time Donor Candidate

Biol Blood Marrow Transplant; ePub 2017 Sep 25; Stoncek, et al

Knowing a repeat donor candidate’s first-time experience and stem cell yields could help transplant centers decide if second donations should occur, researchers concluded after conducting a study involving >22,600 individuals. Investigators compared experiences of 1) second-time donors giving marrow (n=118) to those making only 1 marrow donation (n=5,829) and 2) second-time donors giving peripheral blood stem cells (PBSCs; n=602) to first-time PBSC donors (n=16,095). Among the results:

  • There were no substantial differences in maximum skeletal pain, maximum symptoms, or recovery time between second- and first-time donors.
  • The yield of marrow nucleated cells and PBSC CD34+ cells was lower from second donations.
  • Female (PBSC and marrow) and obese donors (PBSC) had higher skeletal pain and/or toxicity with a second donation.
  • PBSC donors who had significant pain/toxicity with the first donation tended to experience the same with second donation—and they took longer to recover.


Stoncek D, Shaw B, Logan B, et al. Donor experiences of second marrow or peripheral blood stem cell collection mirror the first, but CD34+ yields are less. [Published online ahead of print September 25, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.09.013.

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