Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Shingrix safe in post-transplant patients

Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2

Key clinical point: The adjuvanted herpes zoster vaccine met its efficacy endpoint in myeloma patients after transplant.

Major finding: Efficacy was 68.17% for preventing herpes zoster among HSCT recipients.

Study details: A randomized, observer blind, placebo-controlled phase 3 study of 1,846 post-HSCT recipients.

Disclosures: The study was sponsored by GlaxoSmithKline. Dr. de la Serna reported relationships with multiple pharmaceutical companies.

Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2.

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Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2

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Gene sequencing bone marrow in myelodysplastic syndrome, Duncavage EJ et al. N Engl J Med 2018;379:1028-41.

Levofloxacin prophylaxis in ALL, AML , Alexander S, et al. JAMA. 2018;320(10):995-1004

Genetic markers signal poor prognosis in MCL, Obr A et al. Clin Lymphoma Myeloma Leuk. 2018 Aug 23. doi: 10.1016/j.clml.2018.07.282

Disparities in ALL treatment toxicity, Taylor OA et al. Clin Cancer Res. 2018 Sep 11. doi: 10.1158/1078-0432.CCR-18-0939

Leukemia risk after maternal contraception use, Hargreave M et al. Lancet Oncol. 2018 Sep 6. doi: 10.1016/S1470-2045(18)30479-0

Must Reads in Cellular Therapy

Blood type is diarrhea destiny, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Fertility poor irrespective of conditioning regimen for transplants , Oquendo del Toro H et al. The 2018 Bone Marrow Transplant Tandem Meetings, Abstract 88.

Relapse triggers high rate of haploidentical donor graft failure, Yanir AD et al. Biol Blood Marrow Transplant. doi: 10.1016/j.bbmt.2018.03.001.

Atovaquone associated with increased nocardiosis risk, Molina A et al. Acute Leukemia Forum 2018, Poster Session.