Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Shingrix safe in post-transplant patients

Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2

Key clinical point: The adjuvanted herpes zoster vaccine met its efficacy endpoint in myeloma patients after transplant.

Major finding: Efficacy was 68.17% for preventing herpes zoster among HSCT recipients.

Study details: A randomized, observer blind, placebo-controlled phase 3 study of 1,846 post-HSCT recipients.

Disclosures: The study was sponsored by GlaxoSmithKline. Dr. de la Serna reported relationships with multiple pharmaceutical companies.

Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2.

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Citation:

Source: de la Serna J et al. 2018 BMT Tandem Meetings, Abstract LBA2

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Policy statement on access to opioid medications, Statement on Opioid Use in Patients with Hematologic Diseases and Disorders, American Society of Hematology

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FDA approves pembrolizumab for relapsed/refractory PMBCL, FDA Press Announcement, June 15, 2018; Keytruda Prescribing Information (Drugs@FDA)

Poor adherence to DOAC therapy requires attention, Lakkireddy D et al. Heart Rhythm 2018, Abstract B-LBCT02-03.

Red cell tranfusion may increase risk of postsurgical VTE, Goel R et al. JAMA Surg. 2018 Jun 13. doi: 10.1001/jamasurg.2018.1565

Must Reads in Cellular Therapy

Blood type is diarrhea destiny, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Fertility poor irrespective of conditioning regimen for transplants , Oquendo del Toro H et al. The 2018 Bone Marrow Transplant Tandem Meetings, Abstract 88.

Relapse triggers high rate of haploidentical donor graft failure, Yanir AD et al. Biol Blood Marrow Transplant. doi: 10.1016/j.bbmt.2018.03.001.

Atovaquone associated with increased nocardiosis risk, Molina A et al. Acute Leukemia Forum 2018, Poster Session.