Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Thrombocytopenia in pregnancy raises risk of complications

Reese J et al. N Engl J Med. 2018;379:32-43.

Key clinical point: Platelet counts less than 150,000/mm3 were more common in complicated pregnancies.

Major finding: Platelet counts were below 150,000/mm3 in 11.9% of complicated versus 9.9% of uncomplicated pregnancies at the time of delivery (P = .01).

Study details: Review of records of 7,351 pregnant women delivering at a single site, compared with NHANES data for 8,885 nonpregnant women.

Disclosures: The National Institutes of Health funded the study. The authors reported having no conflicts of interest.

Source: Reese J et al. N Engl J Med. 2018;379:32-43.

Read the article.

Citation:

Reese J et al. N Engl J Med. 2018;379:32-43.

This Week's Must Reads

Observational study shows hydroxyurea well tolerated in sickle cell disease, Dauvergne B et al. FSCDR 2018, presentation JSCDH-D-18-00052

Large cohort study demonstrates DOAC safety vs. warfarin , Vinogradova Y et al. BMJ 2018;362:k2505.

Oral administration of arsenic + ATRA effective for APML, Zhu HH et al. Lancet Oncol. 2018;19:871-9.

Must Reads in Bleeding Disorders

Thrombocytopenia in pregnancy raises risk of complications, Reese J et al. N Engl J Med. 2018;379:32-43.

Red cell tranfusion may increase risk of postsurgical VTE, Goel R et al. JAMA Surg. 2018 Jun 13. doi: 10.1001/jamasurg.2018.1565

Dapagliflozin suppresses hepcidin, boosts hematocrit, Ghanim HA et al. AACE 2018, Abstract 228.

In hemophilia A, reduced frequency prophylaxis was safe, cut costs, Feldman BM et al. Lancet Haematol. 2018 May 3. doi: 10.1016/S2352-3026(18)30048-6.

Reducing morbidity in postpartum hemorrhage, Smith R et al. Annual clinical and scientific meeting of the American Society of Obstetricians and Gynecologists 2018, Abstract 26R.