Key clinical point: Platelet counts less than 150,000/mm3 were more common in complicated pregnancies.
Major finding: Platelet counts were below 150,000/mm3 in 11.9% of complicated versus 9.9% of uncomplicated pregnancies at the time of delivery (P = .01).
Study details: Review of records of 7,351 pregnant women delivering at a single site, compared with NHANES data for 8,885 nonpregnant women.
Disclosures: The National Institutes of Health funded the study. The authors reported having no conflicts of interest.
Source: Reese J et al. N Engl J Med. 2018;379:32-43.
Reese J et al. N Engl J Med. 2018;379:32-43.
This Week's Must Reads
BTK inhibitor shows phase 1 results in Waldenstrom’s macroglobulinemia, Leukemia & Lymphoma 2018
Immune system changes play a role in AML relapse, Christopher MJ et al. N Engl J Med. 2018 Oct 31. doi: 10.1056/NEJMoa1808777.
Haploidentical allo-HCT possible even in relapsed myeloma, Sahebi F, et al. Biol Blood Marrow Transplant. 2018 Sep 20. pii: S1083-8791(18)30575-5.
Venetoclax plus HMA studied in AML, DiNardo C et al. Blood. 2018 Oct 25. doi: 10.1182/blood-2018-08-868752.
The role of PTPN22 R620W in CLL, Leukemia & Lymphoma 2018
Must Reads in Bleeding Disorders
Systematic review examines sickle cell trait complications, Naik RP et al. Ann Intern Med. 2018 Oct 30. doi:10.7326/M18-1161
Cardiovascular risks in hemophilia A, Humphries TJ et al. Adv Med Sci. 2018;63(2):329-33
Study evaluates rapid bacterial testing of platelets, Booth AL et al. AABB18, Abstract INV4
ISTH-BAT is predictive in hemophilia A and B, Borhany M et al. Transfus Apher Sci. 2018 Aug;57(4):556-60
Restricted platelet transfusion yields better outcomes in preterm infants, Curley A et al. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320