Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Extended Thromboprophylaxis After Liver Surgery

J Thromb Haemost; ePub 2017 Sep 27; Kim, et al

People who underwent oncologic liver surgery appeared to benefit from extended pharmacologic thromboprophylaxis, according to a study involving 124 individuals. Participants underwent liver resection between 2013 and 2015 and received extended pharmacologic thromboprophylaxis that included venous thromboembolism prophylaxis intraoperatively and daily during hospitalization. Most also received enoxaparin for 2 weeks or 1 month after discharge, depending on the type of surgery they had. Among the results:

  • Intraoperative transfusion rate was 6%; post-op and overall transfusion rates were 8% and 11%, respectively.
  • There were no postoperative symptomatic deep vein thrombosis or pulmonary embolic events during 90 days of follow-up.
  • No pulmonary emboli or other thoracic, splanchnic, or ileofemoral vein thromboses were seen in those with available CT scans.
  • 2 patients had minor bleeding events until enoxaparin was discontinued.
  • 6% experienced severe complications.
  • There were no deaths at 90 days.

Citation:

Kim B, Day R, Davis C, et al. Extended pharmacologic thromboprophylaxis in oncologic liver surgery is safe and effective. [Published online ahead of print September 27, 2017]. J Thromb Haemost. doi:10.1111/jth.13814.

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