Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cerebral Microbleed Incidence in Hemophilia Studied

Haemophilia; ePub 2017 Dec 28; Husseinzadeh, et al

Cerebral microbleeds (CMBs) appear to be somewhat more common in adults with hemophilia than in people who are hemostatically normal, according to a study involving 63 individuals. Participants either had hemophilia A or B (n=31) or were hemostatically normal (n=32). They underwent MRI brain scans, which investigators reviewed to determine the presence of CMBs. Among the results:

  • HIV and hepatitis C virus infection were more common in patients with hemophilia.
  • Smoking was more common in those who were hemostatically normal.
  • Cardiovascular (CV) risk factors were similar in both groups.
  • CMB prevalence was 35% in patients with hemophilia, vs 25% in hemostatically normal individuals.
  • Advanced age, HCV infection history, and CV risk factors were linked with CMBs in patients with hemophilia.
  • Multiple and large CMBs occurred only in the hemophilia group.

Citation:

Husseinzadeh H, Chiasakul T, Gimotty P, et al. Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B. [Published online ahead of print December 28, 2017]. Haemophilia. doi:10.1111/hae.13398.

This Week's Must Reads

Undertreatment of Newly-Diagnosed MM Evaluated, Clin Lymphoma Myeloma Leuk; ePub 2018 Feb 3; Fakhri, et al

Blacks Fare Better After This Type of Transplant , Biol Blood Marrow Transplant.; ePub 2018 Jan 25; Solomon, et al

Aminocaproic Acid, Bleeding Complications Assessed, Leuk Lymphoma; ePub 2018 Feb 9; Juhl, Roddy, et al

Medication Adherence’s Impact on Outcomes in MM , Clin Lymphoma Myeloma Leuk; ePub 2018 Feb 3; Gupta, et al

FDA Approves Rebinyn to Treat Hemophilia B, Novo Nordisk news release; 2018 Feb 8

Must Reads in Bleeding Disorders

Aminocaproic Acid, Bleeding Complications Assessed, Leuk Lymphoma; ePub 2018 Feb 9; Juhl, Roddy, et al

FDA Approves Rebinyn to Treat Hemophilia B, Novo Nordisk news release; 2018 Feb 8

Platelet Function in ITP Assessed Over Time, Thromb Haemost; 2018 Jan; Frelinger, Grace, et al

Initial Romiplostim Dosing in ITP Evaluated , J Oncol Pharm Pract; ePub 2018 Jan 1; DasGupta, et al

Trends in Pediatric Inpatients with ITP , J Pediatr Hematol Oncol; ePub 2018 Jan 12; Okubo, et al