Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cerebral Microbleed Incidence in Hemophilia Studied

Haemophilia; ePub 2017 Dec 28; Husseinzadeh, et al

Cerebral microbleeds (CMBs) appear to be somewhat more common in adults with hemophilia than in people who are hemostatically normal, according to a study involving 63 individuals. Participants either had hemophilia A or B (n=31) or were hemostatically normal (n=32). They underwent MRI brain scans, which investigators reviewed to determine the presence of CMBs. Among the results:

  • HIV and hepatitis C virus infection were more common in patients with hemophilia.
  • Smoking was more common in those who were hemostatically normal.
  • Cardiovascular (CV) risk factors were similar in both groups.
  • CMB prevalence was 35% in patients with hemophilia, vs 25% in hemostatically normal individuals.
  • Advanced age, HCV infection history, and CV risk factors were linked with CMBs in patients with hemophilia.
  • Multiple and large CMBs occurred only in the hemophilia group.


Husseinzadeh H, Chiasakul T, Gimotty P, et al. Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B. [Published online ahead of print December 28, 2017]. Haemophilia. doi:10.1111/hae.13398.

This Week's Must Reads

Immune system changes play a role in AML relapse, Christopher MJ et al. N Engl J Med. 2018 Oct 31. doi: 10.1056/NEJMoa1808777.

Haploidentical allo-HCT possible even in relapsed myeloma, Sahebi F, et al. Biol Blood Marrow Transplant. 2018 Sep 20. pii: S1083-8791(18)30575-5.

Venetoclax plus HMA studied in AML, DiNardo C et al. Blood. 2018 Oct 25. doi: 10.1182/blood-2018-08-868752.

The role of PTPN22 R620W in CLL, Leukemia & Lymphoma 2018

Must Reads in Bleeding Disorders

Systematic review examines sickle cell trait complications, Naik RP et al. Ann Intern Med. 2018 Oct 30. doi:10.7326/M18-1161

Cardiovascular risks in hemophilia A, Humphries TJ et al. Adv Med Sci. 2018;63(2):329-33

Study evaluates rapid bacterial testing of platelets, Booth AL et al. AABB18, Abstract INV4

ISTH-BAT is predictive in hemophilia A and B, Borhany M et al. Transfus Apher Sci. 2018 Aug;57(4):556-60

Restricted platelet transfusion yields better outcomes in preterm infants, Curley A et al. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320