Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cerebral Microbleed Incidence in Hemophilia Studied

Haemophilia; ePub 2017 Dec 28; Husseinzadeh, et al

Cerebral microbleeds (CMBs) appear to be somewhat more common in adults with hemophilia than in people who are hemostatically normal, according to a study involving 63 individuals. Participants either had hemophilia A or B (n=31) or were hemostatically normal (n=32). They underwent MRI brain scans, which investigators reviewed to determine the presence of CMBs. Among the results:

  • HIV and hepatitis C virus infection were more common in patients with hemophilia.
  • Smoking was more common in those who were hemostatically normal.
  • Cardiovascular (CV) risk factors were similar in both groups.
  • CMB prevalence was 35% in patients with hemophilia, vs 25% in hemostatically normal individuals.
  • Advanced age, HCV infection history, and CV risk factors were linked with CMBs in patients with hemophilia.
  • Multiple and large CMBs occurred only in the hemophilia group.

Citation:

Husseinzadeh H, Chiasakul T, Gimotty P, et al. Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B. [Published online ahead of print December 28, 2017]. Haemophilia. doi:10.1111/hae.13398.

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