Cerebral microbleeds (CMBs) appear to be somewhat more common in adults with hemophilia than in people who are hemostatically normal, according to a study involving 63 individuals. Participants either had hemophilia A or B (n=31) or were hemostatically normal (n=32). They underwent MRI brain scans, which investigators reviewed to determine the presence of CMBs. Among the results:
- HIV and hepatitis C virus infection were more common in patients with hemophilia.
- Smoking was more common in those who were hemostatically normal.
- Cardiovascular (CV) risk factors were similar in both groups.
- CMB prevalence was 35% in patients with hemophilia, vs 25% in hemostatically normal individuals.
- Advanced age, HCV infection history, and CV risk factors were linked with CMBs in patients with hemophilia.
- Multiple and large CMBs occurred only in the hemophilia group.
Husseinzadeh H, Chiasakul T, Gimotty P, et al. Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B. [Published online ahead of print December 28, 2017]. Haemophilia. doi:10.1111/hae.13398.
This Week's Must Reads
FDA postmarketing requirements, Nabhan C et al. JAMA Oncol. 2018 May 10. doi:10.1001/jamaoncol.2018.0610.
Upswing in childhood lymphomas, Siegel DA et al. ASPHO 2018, Abstract 605.
Dapagliflozin suppresses hepcidin, Ghanim HA et al. AACE 2018, Abstract 228.
Methotrexate or nelarabine plus chemo in pediatric T-ALL or T-L, Dunsmore KP et al. ASCO 2018, Abstract 10500.
Blood type is diarrhea destiny, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.
Must Reads in Bleeding Disorders
Reducing morbidity in postpartum hemorrhage, Smith R et al. Annual clinical and scientific meeting of the American Society of Obstetricians and Gynecologists 2018, Abstract 26R.
In sickle cell, start hydroxyurea in infancy, Schuchard S et al. ASPHO 2018, poster # 342 Schuchard S et al. ASPHO 2018, poster # 342. https://onlinelibrary.wiley.com/doi/10.1002/pbc.27057
Increase kidney function monitoring if INR exceeds 4.0, Traquair H et al. biennial summit of the Thrombosis & Hemostasis Societies of North America 2018, Poster 79.
Vaccination lags in children with sickle cell disease, Wagner AL et al. J Pediatr. 2018 May;196:223-9.
Idarucizumab reversed dabigatran despite severe renal dysfunction, Eikelboom JW et al. ACC 18, the annual meeting of the American College of Cardiology, Abstract 1231M-11.