Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cerebral Microbleed Incidence in Hemophilia Studied

Haemophilia; ePub 2017 Dec 28; Husseinzadeh, et al

Cerebral microbleeds (CMBs) appear to be somewhat more common in adults with hemophilia than in people who are hemostatically normal, according to a study involving 63 individuals. Participants either had hemophilia A or B (n=31) or were hemostatically normal (n=32). They underwent MRI brain scans, which investigators reviewed to determine the presence of CMBs. Among the results:

  • HIV and hepatitis C virus infection were more common in patients with hemophilia.
  • Smoking was more common in those who were hemostatically normal.
  • Cardiovascular (CV) risk factors were similar in both groups.
  • CMB prevalence was 35% in patients with hemophilia, vs 25% in hemostatically normal individuals.
  • Advanced age, HCV infection history, and CV risk factors were linked with CMBs in patients with hemophilia.
  • Multiple and large CMBs occurred only in the hemophilia group.


Husseinzadeh H, Chiasakul T, Gimotty P, et al. Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B. [Published online ahead of print December 28, 2017]. Haemophilia. doi:10.1111/hae.13398.

This Week's Must Reads

Higher AML, MDS risk linked to autotransplants, Radivoyevitch T et al. Leuk Res. 2018 Jul 19. pii: S0145-2126(18)30160-7

CMS wants to flatten E/M payments, CMS proposed rule, CMS-1693-P

Lay health workers can assist with end-of-life care, Patel MI et al. JAMA Oncology. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2446.

New guidelines from the UK on chronic lymphocytic leukemia, Schuh AH et al. Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460

JAK1/2 inhibitors tied to increased B-cell lymphoma risk, Porpaczy E et al. Blood. 2018 Jun 14. doi: 10.1182/blood-2017-10-810739.

Must Reads in Bleeding Disorders

Avatrombopag reduces procedure-related transfusions in chronic liver disease and thrombocytopenia, Terrault N et al. Gastroenterology. 2018 May 17. doi: 10.1053/j.gastro.2018.05.025.

Prehospital plasma improves odds of survival in hemorrhagic shock, Sperry JL et al. N Engl J Med. 2018 Jul 26;379(4):315-26.

Thrombocytopenia in pregnancy raises risk of complications, Reese J et al. N Engl J Med. 2018;379:32-43.

Red cell tranfusion may increase risk of postsurgical VTE, Goel R et al. JAMA Surg. 2018 Jun 13. doi: 10.1001/jamasurg.2018.1565

Dapagliflozin suppresses hepcidin, boosts hematocrit, Ghanim HA et al. AACE 2018, Abstract 228.