Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Anticoagulation linked to low BMD in children

Patel KN et al. Thrombosis & Hemostasis Societies of North America 2018, Poster 65.

Key clinical point: Low bone mineral density and vitamin D are not uncommon in chronically anticoagulated children.

Major finding: Of chronically anticoagulated children, 52% were vitamin D deficient and another 24% had insufficient levels of the nutrient.

Study details: A retrospective, single-center cohort study of 50 chronically anticoagulated children.

Disclosures: Dr. Patel reported having no financial disclosures.

Source: Patel KN et al. Thrombosis & Hemostasis Societies of North America 2018, Poster 65.

Read the article.

Citation:

Patel KN et al. Thrombosis & Hemostasis Societies of North America 2018, Poster 65.

This Week's Must Reads

Observational study shows hydroxyurea well tolerated in sickle cell disease, Dauvergne B et al. FSCDR 2018, presentation JSCDH-D-18-00052

Large cohort study demonstrates DOAC safety vs. warfarin , Vinogradova Y et al. BMJ 2018;362:k2505.

Oral administration of arsenic + ATRA effective for APML, Zhu HH et al. Lancet Oncol. 2018;19:871-9.

Must Reads in Bleeding Disorders

Thrombocytopenia in pregnancy raises risk of complications, Reese J et al. N Engl J Med. 2018;379:32-43.

Red cell tranfusion may increase risk of postsurgical VTE, Goel R et al. JAMA Surg. 2018 Jun 13. doi: 10.1001/jamasurg.2018.1565

Dapagliflozin suppresses hepcidin, boosts hematocrit, Ghanim HA et al. AACE 2018, Abstract 228.

In hemophilia A, reduced frequency prophylaxis was safe, cut costs, Feldman BM et al. Lancet Haematol. 2018 May 3. doi: 10.1016/S2352-3026(18)30048-6.

Reducing morbidity in postpartum hemorrhage, Smith R et al. Annual clinical and scientific meeting of the American Society of Obstetricians and Gynecologists 2018, Abstract 26R.