Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Aminocaproic Acid, Bleeding Complications Assessed

Leuk Lymphoma; ePub 2018 Feb 9; Juhl, Roddy, et al

Aminocaproic acid does not seem to lead to a high incidence of thromboembolic complications in people with hematologic malignancies, researchers concluded after conducting a retrospective study involving 109 individuals. Participants with hematologic malignancies had received aminocaproic acid to prevent/treat of thrombocytopenic hemorrhage. Investigators looked for thromboembolic complications confirmed by imaging studies. Among the results:

  • 5% of patients experienced thromboembolic complications; all were venous thromboses.
  • These patients had additional risk factors, such as central venous catheters.

The author noted that the concurrent risk factors may have played a role in thromboses.


Juhl R, Roddy J, Wang T, Li J, Elefritz J. Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies. [Published online ahead of print February 9, 2018]. Leuk Lymphoma. doi:10.1080/10428194.2018.1434882.

This Week's Must Reads

Higher AML, MDS risk linked to autotransplants, Radivoyevitch T et al. Leuk Res. 2018 Jul 19. pii: S0145-2126(18)30160-7

CMS wants to flatten E/M payments, CMS proposed rule, CMS-1693-P

Lay health workers can assist with end-of-life care, Patel MI et al. JAMA Oncology. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2446.

New guidelines from the UK on chronic lymphocytic leukemia, Schuh AH et al. Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460

JAK1/2 inhibitors tied to increased B-cell lymphoma risk, Porpaczy E et al. Blood. 2018 Jun 14. doi: 10.1182/blood-2017-10-810739.

Must Reads in Bleeding Disorders

Avatrombopag reduces procedure-related transfusions in chronic liver disease and thrombocytopenia, Terrault N et al. Gastroenterology. 2018 May 17. doi: 10.1053/j.gastro.2018.05.025.

Prehospital plasma improves odds of survival in hemorrhagic shock, Sperry JL et al. N Engl J Med. 2018 Jul 26;379(4):315-26.

Thrombocytopenia in pregnancy raises risk of complications, Reese J et al. N Engl J Med. 2018;379:32-43.

Red cell tranfusion may increase risk of postsurgical VTE, Goel R et al. JAMA Surg. 2018 Jun 13. doi: 10.1001/jamasurg.2018.1565

Dapagliflozin suppresses hepcidin, boosts hematocrit, Ghanim HA et al. AACE 2018, Abstract 228.