Allogeneic stem cell transplantation (alloSCT) should be considered in patients with double-expressor lymphomas (DEL) and double-hit lymphomas (DHL), researchers concluded after conducting a retrospective analysis involving 78 individuals. Participants underwent alloSCT for relapsed/refractory aggressive B-cell non-Hodgkin lymphoma. Investigators looked at the impact of DEL/DHL status. Among the results:
- 47% had DEL and 13% DHL.
- 4-year progression-free and overall survival rates were similar in patients with and without either DEL or DHL.
- The findings held up after multivariate analysis, though researchers acknowledged the sample size might have prevented detecting significant differences.
Herrera A, Rodig S, Song J, et al. Outcomes after allogeneic stem cell transplantation in patients with double-hit and double-expressor lymphoma. [Published online ahead of print November 28, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.11.023.
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