Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Monetary support affects select prescribing, Mitchell AP et al. JAMA Intern Med. 2018 Apr 9. doi: 0.1001/jamainternmed.2018.0776

Best TKI options in ALL, Jabbour E et al. Clin Lymphoma Myeloma Leuk. 2018 18(4):257-65

2 approaches to diagnosing heparin-induced thrombocytopenia, Pishko A et al. Biennial summit of the Thrombosis & Hemostasis Societies of North America (THSNA) 2018, Abstract 103

Blinatumomab eliminates residual B-cell ALL, Gökbuget N et al. Blood. 2018 Apr 5;131(14):1522-31.

Aryl hydrocarbon receptor antagonist boosts cord blood engraftment, Wagner J et al. 2018 Bone Marrow Transplant Tandem Meetings, Abstract 4.

Clinical Guidelines

Cochrane on Phytomedicines for Sickle Cell Disease , Cochrane; 2018 Feb 15; Oniyangi, Cohall, et al

New Choosing Wisely Guidance on BMT Released , Biol Blood Marrow Transplant; ePub 2018 Jan 19; Bhella, et al

Read more in Clinical Guidelines

Multiple Myeloma

Myeloma more likely to go untreated in dual Medicare-Medicaid recipients, Fakhri B et al. Clin Lymphoma Myeloma Leuk. Mar 2018;18(3):219-24.

In myeloma, go for a third transplant, Garderet L et al. Biol Blood Marrow Transplant. 2018 Feb 3. doi: 10.1016/j.bbmt.2018.01.035

Read more in Multiple Myeloma

CLL

Updated CLL guidelines, Hallek M et al. Blood https://doi.org/10.1182/blood-2017-09-806398

Prognostic Testing Patterns, CLL Outcomes Assessed, Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 5; Mato, et al

Read more in CLL

CML

Treatment-free remission in CML, Mahon FX et al. Ann Intern Med. 2018 Feb 20. doi: 10.7326/M17-1094.

Bosulif Approved to Treat Newly-Diagnosed Ph+ CML, Avillion news release; 2017 Dec 19

Read more in CML

Aggressive Lymphomas

Triggers of Hypercalcemia in Patients with NHL, Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 29; Shallis, et al

Hyperglycemia During Certain Chemo Regimens in NHL, Leuk Lymphoma; ePub 2017 Dec 18; Lamar, et al

Read more in Aggressive Lymphomas

AML

Over half of refractory AML patients responded to combo, Advani A et al. ASH 2017, Abstract 150.

Characteristics of Early ARDS In Patients with AML, Leuk Lymphoma; ePub 2018 Feb 12; Van de Louw, et al

Read more in AML

ALL (Acute Lymphoblastic Leukemia)

Best TKI options in ALL, Jabbour E et al. Clin Lymphoma Myeloma Leuk. 2018 18(4):257-65

Blinatumomab eliminates residual B-cell ALL, Gökbuget N et al. Blood. 2018 Apr 5;131(14):1522-31.

Read more in ALL (Acute Lymphoblastic Leukemia)

Transfusion Medicine

Transfusions don't factor in rheumatoid arthritis transmission, Just SA et al. Ann Rheum Dis. 2018 Mar 1. doi: 10.1136/annrheumdis-2017-212844.

Cochrane Evaluates Red Blood Cell Transfusion Policies, Cochrane Database Syst Rev; 2017 Jan 27; Estcourt, et al

Read more in Transfusion Medicine

Hodgkin Lymphoma

Treatments for Advanced Hodgkin’s Lymphoma Studied, N Engl J Med; 2018 Jan 25; Connors, Jurczak, et al

Chemo-Alone vs Combo Regimens in Advanced NHL , Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 29; Song, et al

Read more in Hodgkin Lymphoma

Indolent Lymphoma

Hyperglycemia During Certain Chemo Regimens in NHL, Leuk Lymphoma; ePub 2017 Dec 18; Lamar, et al

Auto-HCT in People with FL, Early Therapy Failure, Biol Blood Marrow Transplant; ePub 2017 Dec 11; Casulo, et al

Read more in Indolent Lymphoma

Anemia

Testosterone-Anemia Link in Older Men Evaluated , JAMA Intern Med; ePub 2017 Feb 21; Roy, et al

Iron Deficiency Anemia and Hearing Loss , JAMA Otolaryngol Head Neck Surg; ePub 2016 Dec 29; Schieffer, et al

Read more in Anemia

Cellular Therapy

Aryl hydrocarbon receptor antagonist boosts cord blood engraftment, Wagner J et al. 2018 Bone Marrow Transplant Tandem Meetings, Abstract 4.

Cyclophosphamide offers superior GVHD prophylaxis, Bolaños-Meade J et al. 2018 BMT Tandem Meetings, Abstract LB1.

Read more in Cellular Therapy

Mantle Cell Lymphoma

Calquence Approved for Mantle Cell Lymphoma, FDA news release; 2017 Oct 31

Conditioning Regimens for MCL Compared, Biol Blood Marrow Transplant; ePub 2017 Oct 20; Tseng, et al

Read more in Mantle Cell Lymphoma

Mixed Topics

NHL Survivors Tend to Have Impaired Cognition, Cancer; ePub 2017 Sep 15; Ehrhardt, et al

Calcium & Vitamin D Protective Effect Evaluated, Cancer; ePub 2017 Jun 27; Ammann, Drake, et al

Read more in Mixed Topics