Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

FDA postmarketing requirements, Nabhan C et al. JAMA Oncol. 2018 May 10. doi:10.1001/jamaoncol.2018.0610.

Upswing in childhood lymphomas, Siegel DA et al. ASPHO 2018, Abstract 605.

Dapagliflozin suppresses hepcidin, Ghanim HA et al. AACE 2018, Abstract 228.

Methotrexate or nelarabine plus chemo in pediatric T-ALL or T-L, Dunsmore KP et al. ASCO 2018, Abstract 10500.

Blood type is diarrhea destiny, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Clinical Guidelines

Cochrane on Phytomedicines for Sickle Cell Disease , Cochrane; 2018 Feb 15; Oniyangi, Cohall, et al

New Choosing Wisely Guidance on BMT Released , Biol Blood Marrow Transplant; ePub 2018 Jan 19; Bhella, et al

Read more in Clinical Guidelines

Aggressive Lymphomas

Triggers of Hypercalcemia in Patients with NHL, Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 29; Shallis, et al

Hyperglycemia During Certain Chemo Regimens in NHL, Leuk Lymphoma; ePub 2017 Dec 18; Lamar, et al

Read more in Aggressive Lymphomas

AML

Adding statin boosted AML response rate, Advani AS et al. Leuk Res. 2018 Apr;67:17-20.

Pembrolizumab after cytarabine boosts AML response, Zeidner J et al. Acute Leukemia Forum 2018, Poster Session.

Read more in AML

Transfusion Medicine

Dapagliflozin suppresses hepcidin, Ghanim HA et al. AACE 2018, Abstract 228.

Widespread Zika screens not cost effective, Saá P et al. New Engl J Med. 2018;378:1778-88. doi: 10.1056/NEJMoa1714977

Read more in Transfusion Medicine

Hodgkin Lymphoma

Upswing in childhood lymphomas, Siegel DA et al. ASPHO 2018, Abstract 605.

Treatments for Advanced Hodgkin’s Lymphoma Studied, N Engl J Med; 2018 Jan 25; Connors, Jurczak, et al

Read more in Hodgkin Lymphoma

Indolent Lymphoma

Hyperglycemia During Certain Chemo Regimens in NHL, Leuk Lymphoma; ePub 2017 Dec 18; Lamar, et al

Auto-HCT in People with FL, Early Therapy Failure, Biol Blood Marrow Transplant; ePub 2017 Dec 11; Casulo, et al

Read more in Indolent Lymphoma

Cellular Therapy

Blood type is diarrhea destiny, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Fertility poor irrespective of conditioning regimen for transplants , Oquendo del Toro H et al. The 2018 Bone Marrow Transplant Tandem Meetings, Abstract 88.

Read more in Cellular Therapy

Anemia

Testosterone-Anemia Link in Older Men Evaluated , JAMA Intern Med; ePub 2017 Feb 21; Roy, et al

Iron Deficiency Anemia and Hearing Loss , JAMA Otolaryngol Head Neck Surg; ePub 2016 Dec 29; Schieffer, et al

Read more in Anemia

Mantle Cell Lymphoma

Calquence Approved for Mantle Cell Lymphoma, FDA news release; 2017 Oct 31

Conditioning Regimens for MCL Compared, Biol Blood Marrow Transplant; ePub 2017 Oct 20; Tseng, et al

Read more in Mantle Cell Lymphoma

Mixed Topics

NHL Survivors Tend to Have Impaired Cognition, Cancer; ePub 2017 Sep 15; Ehrhardt, et al

Calcium & Vitamin D Protective Effect Evaluated, Cancer; ePub 2017 Jun 27; Ammann, Drake, et al

Read more in Mixed Topics

Myelodysplastic Syndrome

Romiplostim safety confirmed in thrombocytopenic patients with low-risk myelodysplastic syndromes, Kantarjian H et al. The Lancet Haematology March 2018, Pages e117-e126 https://doi.org/10.1016/S2352-3026(18)30016-4

Simplifying the URD Selection Process for HCT, Biol Blood Marrow Transplant.; ePub 2018 Feb 14; Shaw, Logan, et al

Read more in Myelodysplastic Syndrome

Bleeding Disorders

Reducing morbidity in postpartum hemorrhage, Smith R et al. Annual clinical and scientific meeting of the American Society of Obstetricians and Gynecologists 2018, Abstract 26R.

In sickle cell, start hydroxyurea in infancy, Schuchard S et al. ASPHO 2018, poster # 342 Schuchard S et al. ASPHO 2018, poster # 342. https://onlinelibrary.wiley.com/doi/10.1002/pbc.27057

Read more in Bleeding Disorders

Practice Management

FDA postmarketing requirements, Nabhan C et al. JAMA Oncol. 2018 May 10. doi:10.1001/jamaoncol.2018.0610.

Moral Distress in HCT Professionals Evaluated, Biol Blood Marrow Transplant; ePub 2017 Nov 28; Neumann, et al

Read more in Practice Management