Autoimmune Hemolytic Anemia
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Division of Hematology/Medical Oncology Oregon Health & Science University, Portland, OR

Question 1 of 5

You are called to consult on a patient with end-stage liver disease and anemia. The patient’s hematocrit is 25%. He is noted to have a direct antibody test (DAT) that is positive for IgG antibodies but negative for C3. He has a normal lactate dehydrogenase (LDH) level at 185 U/L and a normal reticulocyte count.

What is the next step in the management of this patient?

Consult surgery about splenectomy

Order measurement of ferritin level and additional laboratory tests plus review blood smear looking for other causes of anemia

Start mycophenolate 500 to 1000 mg twice daily

Start prednisone at 1 mg/kg/day

Start rituximab at 375 mg/m2 weekly × 4 weeks

This quiz is not accredited for CME.

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