Management of Advanced Melanoma
Author and Disclosure Information [Show]

Duke University Hospital, Durham, NC.

Question 1 of 5

A 67-year-old woman with a remote history of stage II cutaneous melanoma treated with surgical excision presents to her primary care physician with persistent dry cough and dyspnea for more than 8 weeks. Chest X-ray imaging is concerning for right hilar fullness and bilateral pulmonary nodules. Computed tomography (CT) scan of the chest confirms the presence of multiple bilateral intrapulmonary masses and right-sided hilar lymphadenopathy. The patient undergoes endobronchial ultrasound-guided fine-needle aspiration of the right hilar mass, with histopathology showing metastatic melanoma. BRAF mutation testing is negative for any actionable mutations. The patient’s ECOG performance status is 1.

Which of the following treatment options are appropriate for first-line therapy of this patient’s newly diagnosed metastatic melanoma?

Ipilimumab

Ipilimumab plus nivolumab

Nivolumab

Dabrafenib plus trametinib

B and C are both appropriate

B and D are both appropriate

Hospital Physician: Hematology/Oncology. 2019 April;14(4)

This quiz is not accredited for CME.

More from Board Review Questions: Hematology/Oncology

QUIZ

Autoimmune Hemolytic Anemia
Gastrointestinal Stromal Tumors
Testicular Cancer
Castration-Resistant Prostate Cancer
Transfusion Reactions (part 2)
Transfusion Reactions (part 1)
Plasma Cell Disorders (part 3)
Plasma Cell Disorders (part 2)
Chronic Myeloid Leukemia
Aplastic Anemia
Small Cell Lung Cancer
Management of Metastatic Gastric Cancer
Transfusion Medicine
Management of Colorectal Cancer in Older Adults
Urothelial Carcinoma: Muscle-Invasive and Metastatic Disease
Acute Myeloid Leukemia
Aggressive B-Cell Non-Hodgkin Lymphoma
Pancreatic Adenocarcinoma: Advanced Unresectable and Metastatic Disease
HER2-Positive Breast Cancer
Von Willebrand Disease: Assessment and Diagnostic Testing
Von Willebrand Disease: Clinical Management
Pancreatic Adenocarcinoma: Neoadjuvant and Adjuvant Treatment
Late Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Polycythemia Vera and Essential Thrombocythemia: Current Management
Treatment of Biliary Tract Cancers
Early Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Hairy Cell Leukemia
Genomic Testing in Women with Early-Stage Hormone Receptor–Positive, HER2-Negative Breast Cancer
Immune Thrombocytopenia
Cancer-Related Fatigue
Disseminated Intravascular Coagulation
Advanced Stage and Relapsed/Refractory Hodgkin Lymphoma
Adjuvant Chemotherapy for Colon Cancer
Molecular Markers and Targeted Therapies in the Management of Non-Small Cell Lung Cancer
Metastatic Cutaneous Melanoma: Targeted Therapy and Immunotherapy
Thrombosis in Pregnancy
Locally Advanced Pancreatic Cancer
Early-Stage Hodgkin Lymphoma
Neoadjuvant and Adjuvant Therapy for Gastric Cancer
Hemophilia A and B
Mantle Cell Lymphoma
Soft Tissue Sarcoma
Sickle Cell Disease
Renal Cell Carcinoma
Management of Locally Advanced Rectal Adenocarcinoma
Adjuvant Systemic Therapy for Early-Stage Breast Cancer
Chronic Myeloid Leukemia
Plasma Cell Disorders
Myelodysplastic Syndromes
Acute and Chronic Graft-versus-Host Disease