Von Willebrand Disease: Assessment and Diagnostic Testing
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Natalia Rydz, MD, FRCPC
Clinical Assistant Professor, Division of Hematology and Hematologic Malignancies, Foothills Medical Centre, Calgary AB, Canada

Question 1 of 5

A 30-year-old man presents with prolonged bleeding after a dental extraction. Mild hemophilia A is suspected based on a baseline factor VIII (FVIII) level of 9 IU/dL. Further testing reveals the following: genotyping is negative for an F8 mutation; a desmopressin (DDAVP) trial shows a brisk but short-lived FVIII response; von Willebrand factor antigen (VWF:Ag) level is 0.55 IU/dL; and VWF ristocetin cofactor (VWF:RCo) is 0.50 IU/dL.

What is the next most useful test?

Low-dose ristocetin-induced platelet aggregation

Mixing studies

VWF:collagen binding assay

VWF:FVIII binding assay

VWF multimer analysis

Hospital Physician: Hematology/Oncology. 2018 March;13(2)

This quiz is not accredited for CME.

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