Von Willebrand Disease: Assessment and Diagnostic Testing
Author and Disclosure Information [Show]

Natalia Rydz, MD, FRCPC
Clinical Assistant Professor, Division of Hematology and Hematologic Malignancies, Foothills Medical Centre, Calgary AB, Canada

Question 1 of 5

A 30-year-old man presents with prolonged bleeding after a dental extraction. Mild hemophilia A is suspected based on a baseline factor VIII (FVIII) level of 9 IU/dL. Further testing reveals the following: genotyping is negative for an F8 mutation; a desmopressin (DDAVP) trial shows a brisk but short-lived FVIII response; von Willebrand factor antigen (VWF:Ag) level is 0.55 IU/dL; and VWF ristocetin cofactor (VWF:RCo) is 0.50 IU/dL.

What is the next most useful test?

Low-dose ristocetin-induced platelet aggregation

Mixing studies

VWF:collagen binding assay

VWF:FVIII binding assay

VWF multimer analysis

Hospital Physician: Hematology/Oncology. 2018 March;13(2)

This quiz is not accredited for CME.

More from Board Review Questions: Hematology/Oncology


Management of Advanced Melanoma
Castration-Resistant Prostate Cancer
Transfusion Reactions (part 2)
Transfusion Reactions (part 1)
Plasma Cell Disorders (part 3)
Plasma Cell Disorders (part 2)
Chronic Myeloid Leukemia
Aplastic Anemia
Small Cell Lung Cancer
Management of Metastatic Gastric Cancer
Transfusion Medicine
Acute Myeloid Leukemia
Management of Colorectal Cancer in Older Adults
Urothelial Carcinoma: Muscle-Invasive and Metastatic Disease
Pancreatic Adenocarcinoma: Advanced Unresectable and Metastatic Disease
HER2-Positive Breast Cancer
Aggressive B-Cell Non-Hodgkin Lymphoma
Von Willebrand Disease: Clinical Management
Pancreatic Adenocarcinoma: Neoadjuvant and Adjuvant Treatment
Late Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Polycythemia Vera and Essential Thrombocythemia: Current Management
Treatment of Biliary Tract Cancers
Early Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Hairy Cell Leukemia
Genomic Testing in Women with Early-Stage Hormone Receptor–Positive, HER2-Negative Breast Cancer
Immune Thrombocytopenia
Cancer-Related Fatigue
Disseminated Intravascular Coagulation
Advanced Stage and Relapsed/Refractory Hodgkin Lymphoma
Adjuvant Chemotherapy for Colon Cancer
Molecular Markers and Targeted Therapies in the Management of Non-Small Cell Lung Cancer
Metastatic Cutaneous Melanoma: Targeted Therapy and Immunotherapy
Thrombosis in Pregnancy
Locally Advanced Pancreatic Cancer
Early-Stage Hodgkin Lymphoma
Neoadjuvant and Adjuvant Therapy for Gastric Cancer
Hemophilia A and B
Mantle Cell Lymphoma
Soft Tissue Sarcoma
Sickle Cell Disease
Renal Cell Carcinoma
Management of Locally Advanced Rectal Adenocarcinoma
Adjuvant Systemic Therapy for Early-Stage Breast Cancer
Chronic Myeloid Leukemia
Plasma Cell Disorders
Myelodysplastic Syndromes
Acute and Chronic Graft-versus-Host Disease