Myelodysplastic Syndromes
Author and Disclosure Information [Show]

Jasleen Randhawa, MD
Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

Ehab Atallah, MD
Associate Professor of Medicine, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

Question 1 of 5

Questions 1 and 2 refer to the following case:
A 55-year-old woman presents with progressive fatigue over the past few months. Her past medical history is significant for breast cancer stage IIA diagnosed 5 years ago. Her treatment consisted of mastectomy and locoregional radiation, followed by chemotherapy with adriamycin and cyclophosphamide. On exam, pallor and some bruising on her arms are noted. There is no palpable lymphadenopathy, and the liver and spleen are not palpable. Complete blood count (CBC) shows a white blood cell (WBC) count of 1500/μL, 60% neutrophils, 24% lymphocytes, 12% monocytes, 0% basophils, 2% eosinophils, hemoglobin of 7.5 g/dL, and a platelet count of 80 × 103/μL. The mean corpuscular volume (MCV) is 110 µm3. Other laboratory test results include creatinine 0.8 mg/dL, alanine aminotransferase (ALT) 24 U/L, and aspartate aminotransferase (AST) 20 U/L; levels of B12, folate, and thyrotropin are normal. Erythropoietin level is 36 IU/L.

What cytogenetic abnormality is most likely to be found on analysis of this patient's bone marrow aspirate?

Monosomy 5

Translocation (t) (8;21), or inversion (inv) (16)



Hospital Physician: Hematology/Oncology. 2014 February;9(1)

This quiz is not accredited for CME.

More from Board Review Questions: Hematology/Oncology


Autoimmune Hemolytic Anemia
Gastrointestinal Stromal Tumors
Testicular Cancer
Management of Advanced Melanoma
Castration-Resistant Prostate Cancer
Transfusion Reactions (part 2)
Transfusion Reactions (part 1)
Plasma Cell Disorders (part 3)
Plasma Cell Disorders (part 2)
Chronic Myeloid Leukemia
Aplastic Anemia
Small Cell Lung Cancer
Management of Metastatic Gastric Cancer
Transfusion Medicine
Urothelial Carcinoma: Muscle-Invasive and Metastatic Disease
Acute Myeloid Leukemia
Management of Colorectal Cancer in Older Adults
Pancreatic Adenocarcinoma: Advanced Unresectable and Metastatic Disease
HER2-Positive Breast Cancer
Aggressive B-Cell Non-Hodgkin Lymphoma
Von Willebrand Disease: Assessment and Diagnostic Testing
Von Willebrand Disease: Clinical Management
Pancreatic Adenocarcinoma: Neoadjuvant and Adjuvant Treatment
Late Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Polycythemia Vera and Essential Thrombocythemia: Current Management
Treatment of Biliary Tract Cancers
Early Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Hairy Cell Leukemia
Genomic Testing in Women with Early-Stage Hormone Receptor–Positive, HER2-Negative Breast Cancer
Immune Thrombocytopenia
Cancer-Related Fatigue
Disseminated Intravascular Coagulation
Advanced Stage and Relapsed/Refractory Hodgkin Lymphoma
Adjuvant Chemotherapy for Colon Cancer
Molecular Markers and Targeted Therapies in the Management of Non-Small Cell Lung Cancer
Metastatic Cutaneous Melanoma: Targeted Therapy and Immunotherapy
Thrombosis in Pregnancy
Locally Advanced Pancreatic Cancer
Early-Stage Hodgkin Lymphoma
Neoadjuvant and Adjuvant Therapy for Gastric Cancer
Hemophilia A and B
Mantle Cell Lymphoma
Soft Tissue Sarcoma
Sickle Cell Disease
Renal Cell Carcinoma
Management of Locally Advanced Rectal Adenocarcinoma
Adjuvant Systemic Therapy for Early-Stage Breast Cancer
Chronic Myeloid Leukemia
Plasma Cell Disorders
Acute and Chronic Graft-versus-Host Disease