Metastatic Cutaneous Melanoma: Targeted Therapy and Immunotherapy
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Saro Sarkisian, MD
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
Corey Rearick, BSc
University of Pittsburgh School of Medicine, Pittsburgh, PA
Diwakar Davar, MD, MSc
Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA

Question 1 of 5

A 77-year-old Caucasian man presents with a pigmented lesion on his scalp. Pathology from a shave biopsy reveals a 2.60-mm Breslow, Clark level III, focally ulcerated, superficial spreading melanoma with 1 mitosis/mm2, partial regression, and moderate tumor-infiltrating lymphocytes (TIL) with no evidence of satellitosis or angiolymphatic or perineural invasion. Margins are clear but close at 0.5 mm. Wide local excision and sentinel lymph node biopsy are planned.

Which of the following mutations is most likely to be found on genetic analysis of the primary specimen?

GNA11 c.547C>T (R183C) mutation

NRAS c.38G>T (G13V) mutation

KRAS c.34G>T (G12C) mutation

PIK3CA c.1624G>A (E542K) mutation

SMAD4 c.1081C>T (R361C) mutation

Hospital Physician: Hematology/Oncology. 2017 July;12(4)

This quiz is not accredited for CME.

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