Polycythemia Vera and Essential Thrombocythemia: Current Management
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Lorenzo Falchi, MD
Fellow, Division of Hematology/Oncology, Columbia University Medical Center, New York, NY

Srdan Verstovsek, MD, PhD
Professor of Medicine, Hanns A. Pielenz Clinical Research Center for Myeloproliferative Neoplasms, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Question 1 of 5

A 43-year-old woman presents to the emergency department with a 3-week history of worsening abdominal discomfort and weight gain. She has no medical conditions and takes no medications. On physical examination, a plethoric complexion is noted. The abdomen is tense, tender, and moderately distended. Laboratory findings are notable for a hemoglobin of 180 g/L, white blood cell count of 9000/µL, platelet count of 401 × 103/µL, alanine aminotransferase (ALT) level of 84 U/L, aspartate aminotransferase (AST) of 107 U/L, and total bilirubin level of 0.9 mg/dL. A serum pregnancy test is negative. Abdominal Doppler ultrasonography demonstrates hepatic vein thrombosis.

Which of the following diagnostic tests is most likely to establish the cause of this patient's clinical presentation?

Screening for the JAK2V617F mutation

Hypercoagulability testing

Triple-phase helical computed tomography (CT) of the abdomen

Flow cytometry for CD55 and CD59 expression

Hospital Physician: Hematology/Oncology. 2018 January;13(1)

This quiz is not accredited for CME.

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