Clinical Edge

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No reduction in oral mucositis with folinic acid post transplant

Key clinical point: Folinic acid did not improve rates of severe methotrexate-induced oral mucositis vs. placebo.

Major finding: There were no significant differences in any primary or secondary endpoints in patients treated with folinic acid or placebo.

Study details: Randomized controlled trial of 52 adults receiving methotrexate for GVHD prophylaxis post transplant.

Disclosures: Rabin Medical Center sponsored the trial. Dr. Yeshrun, Dr. Nagler, and Dr. Gilleece reported no relevant conflicts of interest.


Yeshrun M. et al. TCT 2020. Abstract 61.