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Gene sequencing sheds light on outcomes in MPN

Grinfeld J et al. N Engl J Med. 2018;379:1416-30

Key clinical point: Genomic characteristics of patients with myeloproliferative neoplasms (MPN) can predict clinical outcomes.

Major finding: Eight genomic subgroups of MPN were recognized, each with distinct clinical features, including event-free survival, risk of leukemic transformation, and blood counts.

Study details: A gene sequencing study involving 2,035 patients with MPN.

Disclosures: The study was funded by the Wellcome Trust, the National Institute for Health Research Cambridge Biomedical Research Centre, Cancer Research UK, and others. Some study authors reported fees from Celgene, Novartis, Gilead, Shire, and others outside of the study.

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Grinfeld J et al. N Engl J Med. 2018;379:1416-30