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Methotrexate or nelarabine plus chemo in pediatric T-ALL or T-L

Dunsmore KP et al. ASCO 2018, Abstract 10500.

Key clinical point: Regimens combining methotrexate and/or nelarabine with chemo are highly efficacious in children, adolescents, and young adults with T-ALL or T-LL.

Major finding: Patients with T-ALL had a 4-year rate of overall survival of 90.2% and disease-free survival of 84.1%; patients with T-LL had a 4-year rate of overall survival of 85%.

Study details: Phase 3 randomized controlled trial among 1,545 youth with T-ALL or T-LL testing various regimens of methotrexate and/or nelarabine with standard chemotherapy (ALL0434).

Disclosures: Dr. Dunsmore disclosed that an immediate family member is an employee of and has a leadership role with TypeZero; that she receives travel, accommodations, and/or expenses from Novo Nordisk; and that an immediate family member receives travel, accommodations, and/or expenses from Tandem Diabetes Care. The study received funding from the Cancer Therapy Evaluation Program within the National Cancer Institute/National Institutes of Health and received support from the St. Baldrick’s Foundation.

Source: Dunsmore KP et al. ASCO 2018, Abstract 10500.

Citation:

Dunsmore KP et al. ASCO 2018, Abstract 10500.